76193-18-5Relevant academic research and scientific papers
Sulfonation of strychnine and some related compounds by sulfur dioxide - manganese dioxide (the Leuchs reaction)
Edward, John T.,Farrell, Patrick G.,Samad, Syed A.,Wojtowski, Richard,Wong, Sin Cheong
, p. 2380 - 2385 (2007/10/02)
On the basis of pK measurements, 13C nmr, and chemical arguments, the zwitterionic structures 3 and 4 have been assigned to the two minor products obtained by sulfonating strychnine or brucine in water with a mixture of sulfur dioxide and manganese dioxide.The same reagent sulfonates the quaternary salts of strychnine and brucine to give betaines, but fails to sulfonate many other strychnine derivatives as well as a number of other alkaloids examined.
