76212-01-6Relevant academic research and scientific papers
Acyl-isothiocyanates as efficient thiocyanate transfer reagents
Palsuledesai, Charuta C.,Murru, Siva,Sahoo, Santosh K.,Patel, Bhisma K.
supporting information; experimental part, p. 3382 - 3385 (2009/12/01)
An unprecedented transfer of a thiocyanate (-SCN) group from aroyl/acyl isothiocyanate to alkyl or benzylic bromide is observed in the presence of a tertiary amine. This process is most effective when the bromomethyl proton is less acidic, while the prese
Synthesis of N-acyl-1,3-oxathiol-2-imines
Kulka, Marshall
, p. 1557 - 1559 (2007/10/02)
A facile synthesis of N-acyl-1,3-oxathiol-2-imines, 7, is reported.It comprises the reaction of O-alkyl acylcarbamothioates, 4, with 2-chloroketones in the presence of alcoholic sodium alkoxide.The resulting O-alkyl-S-substituted-N-acylcarbonimidothiates, 6, undergo cyclization with elimination of alcohol, spontaneously, or upon heating in boiling toluene to form 7.
Novel Heterocyclizations with Malonic Esters . 1,3-Dithioles; 1,3-Oxathioles; Δ2-Oxazolines and the Vinylene dipyridinium dication
Capuano, Lilly,Bronder, Marott,Hell, Wolfgang,Moersdorf, Peter,Hoge, Reinhold
, p. 899 - 908 (2007/10/02)
The reaction of diethyl bromomalonate (1) or diethyl diazomalonate (6) with benzoyl isothiocyanate (2) proceeds via the carbene intermediates 4,7 or 12 to afford the 1,3-dithiole 5, the Δ2-oxazoline 8 or the 1,3-oxathioles 9 depending upon the catalyst employed.In contrast, the bis(ethoxycarbonyl)methylpyridinium bromides 14 upon treatment with benzoyl isocyanates 15 in pyridine give rise to vinylene dipyridinium dibromides 18.- Keywords: Heterocyclizations; 1H-NMR-Spectroscopy; Iso(thio)cyanates; Malonates
