Cas 76218-83-2,N,N'-bis(2,3-dihydroxybenzoyl)-α,α-diaminopropane

76218-83-2

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Basic information

Product Name: N,N'-bis(2,3-dihydroxybenzoyl)-α,α-diaminopropane
Synonyms: N,N'-bis(2,3-dihydroxybenzoyl)-α,α-diaminopropane
CAS NO:76218-83-2
Molecular Formula:
Molecular Weight: 346.34
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: N,N'-bis(2,3-dihydroxybenzoyl)-α,α-diaminopropane(CAS DataBase Reference)
NIST Chemistry Reference: N,N'-bis(2,3-dihydroxybenzoyl)-α,α-diaminopropane(76218-83-2)
EPA Substance Registry System: N,N'-bis(2,3-dihydroxybenzoyl)-α,α-diaminopropane(76218-83-2)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 76218-83-2(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 76218-83-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,2,1 and 8 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 76218-83:
(7*7)+(6*6)+(5*2)+(4*1)+(3*8)+(2*8)+(1*3)=142
142 % 10 = 2
So 76218-83-2 is a valid CAS Registry Number.

76218-83-2Upstream product

76218-83-2Downstream Products

76218-83-2Relevant academic research and scientific papers

HYDRAZIDE, AMIDE, PHTHALIMIDE AND PHTHALHYDRAZIDE ANALOGS AS INHIBITORS OF RETROVIRAL INTEGRASE

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Page/Page column 28, (2009/04/25)

The present invention provides catechol-containing hydrazides, amides, phthalimide and phthalhydrazide analogs. These compounds are inhibitors of retroviral integrase, an essential enzyme for the proliferation of retroviruses such as HIV-1. Also provided are pharmaceutical compositions comprising at least one of the catechol-containing hydrazides, amides, phthalimide or phthalhydrazide analogs and a method of using the hydrazide, amide, phthalimide and phthalhydrazide analogs to inhibit retroviral proliferation and as therapeutics for the treatment of AIDS.

2,3-Dihydro-6,7-dihydroxy-1H-isoindol-1-one-based HIV-1 integrase inhibitors

Xue, Zhi Zhao,Semenova, Elena A.,Vu, B. Christie,Maddali, Kasthuraiah,Marchand, Christophe,Hughes, Stephen H.,Pommier, Yves,Burke Jr., Terrence R.

, p. 251 - 259 (2008/09/19)

The bis-salicylhydrazides class of HIV-1 integrase (IN) inhibitors has been postulated to function by metal chelation. However, members of this series exhibit potent inhibition only when Mn2+ is used as cofactor. The current study found that bis-aroylhydrazides could acquire inhibitory potency in Mg2+ using dihydroxybenzoyl substituents as both the right and left components of the hydrazide moiety. Employing a 2,3-dihydro-6,7-dihydroxy-1H- isoindol-1-one ring system as a conformationally constrained 2,3-dihydroxybenzoyl equivalent provided good selectivity for IN-catalyzed strand transfer versus the 3′-processing reactions as well as antiviral efficacy in cells using HIV-1 based vectors.

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