762222-15-1

Basic information

• Product Name: methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(1-methylpiperizin-4-ylcarbamoyl)-2-phenylvinyl]-2-butenoate
• CAS NO: 762222-15-1
• Molecular Weight: 478.588
• Mol File: 762222-15-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(1-methylpiperizin-4-ylcarbamoyl)-2-phenylvinyl]-2-butenoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(1-methylpiperizin-4-ylcarbamoyl)-2-phenylvinyl]-2-butenoate(762222-15-1)
• EPA Substance Registry System: methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(1-methylpiperizin-4-ylcarbamoyl)-2-phenylvinyl]-2-butenoate(762222-15-1)

Safety Data

• Hazardous Substances Data: 762222-15-1(Hazardous Substances Data)

Upstream product

• 41838-46-4 4-Amino-1-methylpiperidine 
• 197979-53-6 2-[1-(3',5'-dimethoxyphenyl)-(Z)-ethylidene]-3-[1-phenyl-(E)-methylidene]-succinic acid 1-methyl ester 

Downstream Products

• 197979-73-0 methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(1-methylpiperizin-4-ylcarbamoyl)-2-phenylvinyl]-2-butenoate hydrochloride 

Relevant articles and documents

Synthesis and evaluation of 1,4-diphenylbutadiene derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) production

Butadiene-imide 1 (T-686) derivatives were synthesized and evaluated for their inhibitory activity against PAI-1 production and their ADMET (DMPK and toxicology) profiles. Among these derivatives, compound 15k (T-2639) showed good antithrombotic activity in two rat thrombosis models without affecting bleeding time, indicating reduction of haemorrhagic risk. We also describe in this report a practical synthesis of 15k suitable for scale-up using Z,E-selective Stobbe condensation.