197979-53-6

Upstream product

• 39151-19-4 1-(3,5-dimethoxyphenyl)ethan-1-one 
• 65859-90-7 dimethyl (E)-benzylidenesuccinate 
• 1094172-77-6 C₂₄H₂₆O₇ 

Downstream Products

• 197979-66-1 methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(4-methylpiperazin-1-ylcarbamoyl)-2-phenylvinyl]-2-butenoate 
• 1094209-03-6 methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-2-phenyl-1-(quinolin-8-ylcarbamoyl)vinyl]-2-butenoate 
• 1094172-83-4 methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-2-phenyl-1-(tetrazol-5-ylcarbamoyl)vinyl]-2-butenoate 
• 197980-15-7 methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-((E)-2-phenyl-1-[(pyridin-4-ylmethyl)carbamoyl]vinyl)-2-butenoate 
• 1094209-02-5 methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-((E)-2-phenyl-1-[(pyridin-3-ylmethyl)carbamoyl]vinyl)-2-butenoate 
• 785758-23-8 methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-2-phenyl-1-([1,2,4]-triazol-4-ylcarbamoyl)vinyl]-2-butenoate 
• 777839-66-4 methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-2-phenyl-1-(pyrimidin-2-ylcarbamoyl)vinyl]-2-butenoate 
• 739349-45-2 methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-2-phenyl-1-(pyridin-4-ylcarbamoyl)vinyl]-2-butenoate 
• 738564-61-9 methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-2-phenyl-1-(pyridin-3-ylcarbamoyl)vinyl]-2-butenoate 
• 762222-15-1 methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(1-methylpiperizin-4-ylcarbamoyl)-2-phenylvinyl]-2-butenoate 
• 769101-35-1 C₂₇H₃₂N₂O₅ 

Relevant academic research and scientific papers

Synthesis and evaluation of 1,4-diphenylbutadiene derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) production

Butadiene-imide 1 (T-686) derivatives were synthesized and evaluated for their inhibitory activity against PAI-1 production and their ADMET (DMPK and toxicology) profiles. Among these derivatives, compound 15k (T-2639) showed good antithrombotic activity in two rat thrombosis models without affecting bleeding time, indicating reduction of haemorrhagic risk. We also describe in this report a practical synthesis of 15k suitable for scale-up using Z,E-selective Stobbe condensation.

Practical synthetic method of (2Z,3E)-1,4-Diphenylbutadiene T-2639, an inhibitor of plasminogen activator inhibitor-1 (PAI-1) production

A practical synthetic method of (2Z,3E)-1,4-diphenylbutadiene derivative T-2369 (1), a potent inhibitor of plasminogen activator inhibitor-1 (PAI-1) production, is described. Conditions of Stobbe condensation in the conventional synthesis of T-2369 were e

Design, synthesis, and evaluation of orally active inhibitors of plasminogen activator inhibitor-1 (PAI-1) production

A novel series of butadiene-imide 1 (T-686) derivatives having an inhibitory activity against PAI-1 production was synthesized and evaluated their biological activities and DMPK profiles, in which 15k (T-2639) was selected as the best compound based on its strong antithrombotic activity and good bioavailability.