762233-34-1

Usage

Uses

Used in Pharmaceutical Development:
1-benzyl 2-methyl (2S,4R)-4-aminopyrrolidine-1,2-dicarboxylate is used as a starting material in the synthesis of various drugs. Its unique structure allows for the creation of new compounds with potential therapeutic effects, making it a valuable asset in the development of novel pharmaceuticals.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 1-benzyl 2-methyl (2S,4R)-4-aminopyrrolidine-1,2-dicarboxylate serves as a reference compound for analytical purposes. Its distinct properties and reactivity can be used to study and understand the mechanisms of drug action, as well as to develop new methods for drug synthesis and analysis.
Used in Drug Synthesis:
1-benzyl 2-methyl (2S,4R)-4-aminopyrrolidine-1,2-dicarboxylate is used as an intermediate in the synthesis of complex drug molecules. Its ability to form various chemical bonds and its compatibility with different synthetic routes make it a versatile building block in the creation of new pharmaceutical agents.
Used in Analytical Chemistry:
As a reference compound, 1-benzyl 2-methyl (2S,4R)-4-aminopyrrolidine-1,2-dicarboxylate is used in analytical chemistry to calibrate instruments and develop methods for the detection and quantification of related compounds. Its well-defined structure and properties make it an ideal standard for ensuring the accuracy and reliability of analytical results.

Upstream product

• 189215-87-0 (2S,4S)-4-(4-Nitro-benzoyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 189215-90-5 1-benzyl 2-methyl (2S,4R)-4-(tert-butoxycarbonylamino)pyrrolidine-1,2-dicarboxylate 
• 1035596-36-1 (2S,4R)-1-benzyl 2-methyl 4-(1,3-dioxoisoindolin-2-yl)pyrrolidine-1,2-dicarboxylate 
• 501-53-1 benzyl chloroformate 
• 189215-88-1 1-benzyl 2-methyl (2S,4S)-4-((methylsulfonyl)oxy)pyrrolidine-1,2-dicarboxylate 
• 57653-35-7 (2S,4S)-4-hydroxypyrrolidine-1,2-dicarboxylic acid 1-benzyl 2-methyl 
• 64187-48-0 methyl (2S,4R)-1-benzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylate 
• 189215-89-2 (2S,4R)-N-1-(benzyloxycarbonyl)-4-azidoproline methyl ester 

Downstream Products

• 189215-90-5 1-benzyl 2-methyl (2S,4R)-4-(tert-butoxycarbonylamino)pyrrolidine-1,2-dicarboxylate 
• 1035596-37-2 (2S,4R)-1-benzyl 2-methyl 4-benzamidopyrrolidine-1,2-dicarboxylate 
• 1163706-99-7 (2S,4R)-4-dimethylamino-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 189215-92-7 (2S,4R)-1-[2-(4-Benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-4-tert-butoxycarbonylamino-pyrrolidine-2-carboxylic acid methyl ester 
• 473806-21-2 4-tertbutyloxycarbonylamino-L-trans-proline methyl ester 
• 803706-19-6 (2S,4R)-4-({(2S,4R)-1-Benzyloxycarbonyl-4-[((2S,4R)-1-benzyloxycarbonyl-4-tert-butoxycarbonylamino-pyrrolidine-2-carbonyl)-amino]-pyrrolidine-2-carbonyl}-amino)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 
• 489453-07-8 (2S,4R)-4-({(2S,4R)-1-Benzyloxycarbonyl-4-[((2S,4R)-1-benzyloxycarbonyl-4-tert-butoxycarbonylamino-pyrrolidine-2-carbonyl)-amino]-pyrrolidine-2-carbonyl}-amino)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 489453-06-7 (2S,4R)-4-[((2S,4R)-1-Benzyloxycarbonyl-4-tert-butoxycarbonylamino-pyrrolidine-2-carbonyl)-amino]-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 

Relevant academic research and scientific papers

Dihydropyridine compound and application thereof to drugs

The invention relates to a dihydropyridine compound and application of the dihydropyridine compound serving as a drug, in particular to application of the dihydropyridine compound serving as a drug for treating and preventing hepatitis B. Specifically, the invention relates to the compound shown as the general formula (I) or (Ia) (please see the specifications for the general formula (I) or (Ia))or stereoisomers, tautomer, a nitrogen oxide, solvate, metabolites and medically acceptable salt of the compound or a prodrug of the compound, wherein all variables are defined in the specification. The invention further relates to application of the compound shown as the general formula (I) or (Ia) or enantiomers, non-enantiomers, the tautomer, hydrates, the solvate or the medically acceptable salt of the compound serving as drugs, in particular to application of the compound or the enantiomers, the non-enantiomers, the tautomer, the hydrates, the solvate or the medically acceptable salt of the compound serving as the drugs for treating and preventing hepatitis B.

SYNTHESIS OF PYRROLIDINE COMPOUNDS

Provided are methods for the preparation of certain substituted pyrrolidine compounds, forms of (2S, 4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride, and methods for preparing and using these forms.

Synthesis of new building blocks for peptide nucleic acids containing monomers with variations in the backbone

New PNA monomers containing aminoprolines or pyrrolidines as backbones have been synthesized. Oligomerisation was carried out on a solid support. Resistance to enzymatic degradation was tested.