762266-07-9

Basic information

• Product Name: 4-(bis(4-fluorophenyl)(hydroxy)Methyl) -3-(hydroxyMethyl)benzonitrile
• Synonyms: 4-(bis(4-fluorophenyl)(hydroxy)Methyl) -3-(hydroxyMethyl)benzonitrile
• CAS NO: 762266-07-9
• Molecular Formula: C₂₁H₁₅F₂NO₂
• Molecular Weight: 351.3461064
• Mol File: 762266-07-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(bis(4-fluorophenyl)(hydroxy)Methyl) -3-(hydroxyMethyl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(bis(4-fluorophenyl)(hydroxy)Methyl) -3-(hydroxyMethyl)benzonitrile(762266-07-9)
• EPA Substance Registry System: 4-(bis(4-fluorophenyl)(hydroxy)Methyl) -3-(hydroxyMethyl)benzonitrile(762266-07-9)

Safety Data

• Hazardous Substances Data: 762266-07-9(Hazardous Substances Data)

Upstream product

• 82104-74-3 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile 
• 352-13-6 4-flourophenylmagnesium bromide 

Downstream Products

• 762266-09-1 1,1-bis(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile 
• 64169-67-1 1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile 
• 207680-98-6 4-[(4-fluoro-phenyl)-hydroxy-methyl]-3-hydroxymethyl-benzonitrile 

Relevant articles and documents

Preparation method of escitalopram process impurities

The invention relates to a preparation method of escitalopram process impurities. The escitalopram process impurities are obtained by reaction of 5-cyanophthalide with 4-fluorophenylmagnesium bromide.The process is simple and the yield is high.

PROCESS FOR THE PREPARATION OF A CYANO-ISOBENZOFURAN

A process for the preparation of citalopram and the pharmaceutically acceptable salts therof is disclosed by reacting 5-cyanophthalide with a 4-fluorophenyl magnesium halide, reducing the 3-hydroxymethyl-4-(4-fluoro-benzoyl)benzonitrile with an agent reducing ketones to alcohols, submitting the thus-obtained 3-hydroxymethyl-4- [(4-fluorophenyl)hydroxymethyl) benzonitrile to a cyclization reaction to give 1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile without 1,1-bis(4-fluorophenyl)-1,3-dihydro-5- isobenzofurancarbonitrile and treating 1,1-bis(4 fluorophenyl)-1,3-dihydro-5- isobenzofurancarbonitrile with a 3-(dimetylamino)propyl halide in the presence of a base.