76227-28-6Relevant academic research and scientific papers
Purines. XXIII. Synthesis of N6-Alkoxy-1,3-dialkyladeninium Salts and an Attempt to Synthesize 1,3-Dimethyladenine
Fujii, Tozo,Saito, Tohru,Nakasaka, Tsuyoshi
, p. 3521 - 3527 (2007/10/02)
Ethylation of N6-methoxy-3-methyladenine (5) with EtI in AcNMe2 gave the 1-ethylated product 8 (X=I) (21percent yield) and the N6-ethylated product 11 (X=ClO4) (33percent).The N6-benzyloxy analogue 6, prepared from 3-methy
Synthesis, Ring Opening, and Glycosidic Bond Cleavage of 3-Methyl-2'-deoxyadenosine
Fujii, Tozo,Saito, Tohru,Nakasaka, Tsuyoshi
, p. 758 - 759 (2007/10/02)
Methylation of N'-benzyloxy-1-(2-deoxy-β-D-ribofuranosyl)-5-formamidoimidazole-4-carboxamidine (2a) followed by hydrogenolysis of the N'-benzyloxy-group and cyclization produced the hitherto unknown 3-methyl-2'-deoxyadenosine (5a), which was readily hydrolysed to 3-methyladenine (6) in H2O at pH /=7.0 and to (6) and the imidazole-(2-deoxy)riboside (4a) at pH 8.98.
