762273-00-7

Upstream product

• 7391-31-3 2-ethyl-3-oxo-3-phenylpropanenitrile 
• 614-16-4 Benzoylacetonitrile 
• 24424-99-5 di-tert-butyl dicarbonate 
• 130194-42-2 (1S)-3-amino-1-phenyl-1-propanol 
• 132203-26-0 (S)-3-hydroxy-3-phenylpropanenitrile 
• 257892-43-6 (+/-)-N-(tert-butoxycarbonyl)-3-amino-1-phenylpropan-1-ol 
• 333387-97-6 (3-oxo-3-phenylpropyl)carbamic acid tert-butyl ester 
• 5053-63-4 3-amino-1-phenylpropan-1-ol 
• 73627-97-1 3-hydroxy-3-phenylpropanenitrile 

Downstream Products

• 1147272-60-3 C₂₄H₂₈ClN₇O₄ 
• 130194-42-2 (1S)-3-amino-1-phenyl-1-propanol 
• 114133-37-8 (S)-N-methyl-3-amino-1-phenyl-1-propanol 

Relevant academic research and scientific papers

Simple 1,3-diamines and their application as ligands in ruthenium(II) catalysts for asymmetric transfer hydrogenation of aryl ketones

In this research work simple unsymmetrical 1,3-diamines were studied. The synthesis of the diamines started from non-commercial available compounds. S-5a and S,S-5c were obtained by biocatalysis with non conventional yeast, Rhodotorula rubra MIM 147, with

The palladium-catalyzed aerobic kinetic resolution of secondary alcohols: Reaction development, scope, and applications

The first palladium-catalyzed enantioselective oxidation of secondary alcohols has been developed, utilizing the readily available diamine (-)-sparteine as a chiral ligand and molecular oxygen as the stoichiometric oxidant. Mechanistic insights regarding the role of the base and hydrogen-bond donors have resulted in several improvements to the original system. Namely, addition of cesium carbonate and tert-butyl alcohol greatly enhances reaction rates, promoting rapid resolutions. The use of chloroform as solvent allows the use of ambient air as the terminal oxidant at 23°C, resulting in enhanced catalyst selectivity. These improved reaction conditions have permitted the successful kinetic resolution of benzylic, allylic, and cyclopropyl secondary alcohols to high enantiomeric excess with good-toexcellent selectivity factors. This catalyst system has also been applied to the desymmetrization of meso-diols, providing high yields of enantioenriched hydroxyketones.

The resolution of important pharmaceutical building blocks by palladium-catalyzed aerobic oxidation of secondary alcohols

The palladium-catalyzed aerobic oxidative kinetic resolution of key pharmaceutical building blocks is described. Substrates investigated are relevant to the enantioselective preparation of Prozac, Singulair, and the promising hNK-1 receptor antagonist from Merck. The latter provides the most selective aerobic oxidative kinetic resolution yet described.