76228-12-1

Upstream product

• 5634-63-9 diethyl 4-oxo-1-phenylazetidine-2,2-dicarboxylate 
• 110-86-1 pyridine 

Downstream Products

• 65837-49-2 4-hydroxymethyl-1-phenyl-2-azetidinone 
• 81942-10-1 4-methyl-1-phenylazetidine-2-one 
• 103841-35-6 4-bromomethyl-1-phenylazetidin-2-one 
• 86694-83-9 4-iodomethyl-1-phenylazetidin-2-one 
• 94271-42-8 4-cyanomethyl-1-phenylazetidin-2-one 
• 103841-28-7 4-acetoxymethyl-1-phenylazetidin-2-one 
• 103841-38-9 4-oxo-1-phenylazetidin-2-ylmethyl nitrate 
• 103841-42-5 4-benzylthiomethyl-1-phenylazetidin-2-one 
• 103841-45-8 4-({[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-amino}-methyl)-1-phenyl-azetidin-2-one 
• 103841-43-6 4-azidomethyl-1-phenylazetidin-2-one 
• 103841-32-3 1-phenyl-4-(phenylcarbamoyloxymethyl)azetidin-2-one 
• 103841-44-7 C₂₈H₂₅N₂OP 
• 103841-46-9 (4-oxo-1-phenylazetidin-2-ylmethyl)ammonium chloride 
• 103841-47-0 N-(4-oxo-1-phenylazetidin-2-ylmethyl)pyridinium iodide 

Relevant academic research and scientific papers

Heterocyclic compounds containing an alkoxycarbonyl and a substituted methyl group

The invention relates to new heterocyclic compound containing an alkoxycarbonyl and a substituted methyl group a process for the preparation of these and analogeous compound and pharmaceutical compositions containing them. More particularly, the invention concerns compounds of the general formula (IVa) STR1 wherein R' is hydrogen, 2-ethoxycarbonylethyl, aryl or a group suitable for a temporary protection of amides and Y' represents a group of the formula --COOZ or --CH2 M, in which Z is lower alkyl and M is hydroxyl, halogen, cyano or a group of the formula --O--SO2 R2, in which R2 is lower alkyl or aryl, with the proviso that if R' is phenyl, Y' cannot stand for the group --COOC2 H5. The invention further relates to a process for the preparation of compounds of the general formula (IV) STR2 in which R and Y are identical with R' and Y', respectively, except the proviso. According to a further aspect of the invention there are provided pharmaceutical compositions, first of all with antihypoxic activity, comprising compounds of the general formula (IVa) as active ingredient.

Efficient Synthesis of 1-Aryl-4-oxo-azetidine-2-carboxylic Acid-ethylesters

The dehalogenation of the 1-aryl-3-chloro-4-oxo-azetidine-2-carboxylic acid-ester (3a-d) and (4a-d), which may be obtained by the addition of chloroketene to the aniles (2a-d) leads to the title compounds in good yield. - Key words: Aryloximinoacetic acid