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Usage

Uses

Used in Pharmaceutical Industry:
2,2-Azetidinedicarboxylic acid, 4-oxo-1-phenyl-, diethyl ester is used as a sedative-hypnotic drug for the treatment of insomnia. It is effective in addressing sleep problems by modulating the unbalanced chemicals in the brain, providing a rapid onset of action and short half-life, making it suitable for short-term use.
Used in Sleep Aid Applications:
Zaleplon is used as a sleep aid to help individuals with insomnia achieve a restful night's sleep. Its rapid onset of action and short half-life make it an effective option for those seeking temporary relief from sleep disorders.
Used in Healthcare Supervision:
2,2-Azetidinedicarboxylic acid, 4-oxo-1-phenyl-, diethyl ester is used under the supervision of healthcare professionals to ensure safe and effective treatment. This is important due to its potential for abuse or dependence if used long-term, and to monitor the appropriate dosage and duration of use for each individual patient.

Upstream product

• 5326-87-4 N-(phenyl)bromoacetamide 
• 685-87-0 Diethyl 2-bromomalonate 
• 6414-58-0 diethyl 2-phenylaminomalonate 
• 587-65-5 N-chloroacetyl-aniline 
• 34642-61-0 diethyl 2-(2-bromo-N-phenylacetamido)malonate 

Downstream Products

• 96296-41-2 4-oxo-1-phenyl-azetidine-2,2-dicarboxylic acid monoethyl ester 
• 855269-32-8 1-cyclohexyl-4-oxo-azetidine-2,2-dicarboxylic acid diethyl ester 
• 76228-12-1 4-Oxo-1-phenyl-azetidin-2-carbonsaeure-ethylester 
• 111781-69-2 diethyl 1-(o-nitrophenyl)-4-oxoazetidine-2,2-dicarboxylate 
• 22815-43-6 1-(p-nitrophenyl)-4-oxoazetidine-2,2-dicarboxylate 
• 81942-10-1 4-methyl-1-phenylazetidine-2-one 
• 65837-49-2 4-hydroxymethyl-1-phenyl-2-azetidinone 
• 103841-35-6 4-bromomethyl-1-phenylazetidin-2-one 
• 86694-83-9 4-iodomethyl-1-phenylazetidin-2-one 
• 94271-42-8 4-cyanomethyl-1-phenylazetidin-2-one 
• 103841-28-7 4-acetoxymethyl-1-phenylazetidin-2-one 
• 103841-38-9 4-oxo-1-phenylazetidin-2-ylmethyl nitrate 
• 103841-42-5 4-benzylthiomethyl-1-phenylazetidin-2-one 
• 103841-45-8 4-({[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-amino}-methyl)-1-phenyl-azetidin-2-one 

Relevant academic research and scientific papers

Reactivity of electrogenerated N-heterocyclic carbenes in room-temperature ionic liquids. Cyclization to 2-azetidinone ring via C-3/C-4 bond formation

The intrinsic chemistry of imidazolium-based room-temperature ionic liquids, related to the acidity of the C-2 imidazolium cation, can be modified via cathodic cleavage of the C-2/hydrogen bond. N-Heterocyclic carbenes, electrogenerated by electrolysis of

Electrochemical Studies on Haloamides. Part 4. Reactivity of Haloacetamides and Haloacetohydroxamates Toward Electrogenerated Diethyl Malonate Anion

The reactivity of haloacetamides and acetohydroxamates 1 and 2 toward electrogenerated diethyl malonate anion has been investigated.The course of the reaction primarily depends on the acidity of the amide NH group, which is mainly determined by the nature of the substituent, R, at the nitrogen atom.If this substituent is the same, the nature of the halogen atom also plays an important role.If the malonate anion can act as a base, products arising from follow-up reactions of the conjugated base of the substrate are formed and their structure is dependent on R.In particular, β-lactams arising from a formal insertion of a malonate residue into the amide skeleton are obtained from haloacetanilides.When the substrate cannot be deprotonated, the diethyl malonate anion behaves as a nucleophile provided that the leaving group is bromide.Chloro derivatives are rather stable toward malonate anion.

Electrochemical Behaviour of ο-Bromoalkanamides. Electrosynthesis of β-, γ-, and δ-Lactams

The electrochemical behaviour of bromoamides 1-3 in dimethylformamide solution at a Hg cathode has been investigated by means of cyclic voltammetry at various scan rates and controlled-potential electrolysis.All compounds undergo a facile, high yielding r