762285-62-1

Basic information

• Product Name: {(S)-1-[((R)-1-Benzyl-pyrrolidin-3-yl)-methyl-carbamoyl]-pyrrolidin-3-yl}-methyl-carbamic acid tert-butyl ester
• Synonyms: {(S)-1-[((R)-1-Benzyl-pyrrolidin-3-yl)-methyl-carbamoyl]-pyrrolidin-3-yl}-methyl-carbamic acid tert-butyl ester
• CAS NO: 762285-62-1
• Molecular Weight: 416.564
• Mol File: 762285-62-1.mol

Chemical Properties

• CAS DataBase Reference: {(S)-1-[((R)-1-Benzyl-pyrrolidin-3-yl)-methyl-carbamoyl]-pyrrolidin-3-yl}-methyl-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {(S)-1-[((R)-1-Benzyl-pyrrolidin-3-yl)-methyl-carbamoyl]-pyrrolidin-3-yl}-methyl-carbamic acid tert-butyl ester(762285-62-1)
• EPA Substance Registry System: {(S)-1-[((R)-1-Benzyl-pyrrolidin-3-yl)-methyl-carbamoyl]-pyrrolidin-3-yl}-methyl-carbamic acid tert-butyl ester(762285-62-1)

Safety Data

• Hazardous Substances Data: 762285-62-1(Hazardous Substances Data)

Upstream product

• 169750-01-0 (S)-3-[N-(tert-butoxycarbonyl)-N-methylamino]pyrrolidine 
• 762285-93-8 ((R)-1-benzylpyrrolidin-3-yl)-methyl-carbamic acid 4-nitrophenyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 762286-24-8 (S)-3-(methylamino)pyrrolidine-1-carboxylic acid [(R)-1-benzylpyrrolidin-3-yl]-N-methylamide 
• 75677-02-0 3-(4-chlorophenyl)propionaldehyde 
• 392338-15-7 tert-butyl [(3R)-pyrrolidin-3-yl]methylcarbamate 
• 144043-17-4 (3R)-1-benzyl-N-methylpyrrolidin-3-amine 
• 862847-07-2 (R)-3-Hydroxy-pyrrolidine-1-carboxylic acid ((R)-1-benzyl-pyrrolidin-3-yl)-methyl-amide 

Downstream Products

• 794479-71-3 (S)-3-[Methyl-(4'-trifluoromethyl-biphenyl-4-carbonyl)-amino]-pyrrolidine-1-carboxylic acid {(R)-1-[3-(4-chloro-phenyl)-propyl]-pyrrolidin-3-yl}-methyl-amide 
• 762286-00-0 (S)-3-[Methyl-(4'-trifluoromethyl-biphenyl-4-carbonyl)-amino]-pyrrolidine-1-carboxylic acid [(R)-1-(2-hydroxy-ethyl)-pyrrolidin-3-yl]-methyl-amide 
• 762285-94-9 [(S)-1-({(R)-1-[3-(4-Chloro-phenyl)-propyl]-pyrrolidin-3-yl}-methyl-carbamoyl)-pyrrolidin-3-yl]-methyl-carbamic acid tert-butyl ester 
• 848464-76-6 [(S)-1-({(R)-1-[2-(4-Chloro-phenoxy)-ethyl]-pyrrolidin-3-yl}-methyl-carbamoyl)-pyrrolidin-3-yl]-methyl-carbamic acid tert-butyl ester 
• 762283-05-6 ((S)-1-{[(R)-1-(4,4-Dimethyl-cyclohexyl)-pyrrolidin-3-yl]-methyl-carbamoyl}-pyrrolidin-3-yl)-methyl-carbamic acid tert-butyl ester 

Relevant articles and documents

Synthesis and structure-activity relationships of biarylcarboxamide bis-aminopyrrolidine urea derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1)

A novel series of bis-aminopyrrolidine ureas containing either a 4-biphenylcarboxmide or 5-phenyl-2-thiophenecarboxamide group have been identified as potent and functional antagonists of the melanin-concentrating hormone receptor-1. Syntheses and SAR are

Bis(aminopyrrolidine)-derived ureas (APUs) as potent MCH1 receptor antagonists

Ureas derived from two substituted 3-aminopyrrolidine subunits were prepared as constrained analogs of a linear lead compound and tested as antagonists of the MCH1 receptor. The series was optimized for substitution and stereochemistry to generate a functional antagonist with a Ki of 3.3 nM and IC50 of 12 nM (GTPγS).

MELANIN-CONCENTRATING HORMONE RECEPTOR ANTAGONISTS AND COMPOSITIONS AND METHODS RELATED THERETO

Melanin-concentrating hormone (MCH) receptor antagonists are disclosed having utility for the treatment of MCH receptor-based disorders such as obesity. The compounds of this invention have the following structure: including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein m, n, X, R1, R2, R3, R4, and R5 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.