762286-16-8

Basic information

• Product Name: ((S)-1-{[(S)-1-(4,4-Dimethyl-cyclohexyl)-pyrrolidin-3-yl]-methyl-carbamoyl}-pyrrolidin-3-yl)-methyl-carbamic acid tert-butyl ester
• CAS NO: 762286-16-8
• Molecular Weight: 436.638
• Mol File: 762286-16-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ((S)-1-{[(S)-1-(4,4-Dimethyl-cyclohexyl)-pyrrolidin-3-yl]-methyl-carbamoyl}-pyrrolidin-3-yl)-methyl-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: ((S)-1-{[(S)-1-(4,4-Dimethyl-cyclohexyl)-pyrrolidin-3-yl]-methyl-carbamoyl}-pyrrolidin-3-yl)-methyl-carbamic acid tert-butyl ester(762286-16-8)
• EPA Substance Registry System: ((S)-1-{[(S)-1-(4,4-Dimethyl-cyclohexyl)-pyrrolidin-3-yl]-methyl-carbamoyl}-pyrrolidin-3-yl)-methyl-carbamic acid tert-butyl ester(762286-16-8)

Safety Data

• Hazardous Substances Data: 762286-16-8(Hazardous Substances Data)

Upstream product

• 4255-62-3 4,4-dimethylcyclohexane-1-one 
• 762285-87-0 Methyl-[(S)-1-((S)-methyl-pyrrolidin-3-yl-carbamoyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester 
• 762285-86-9 {(S)-1-[((S)-1-Benzyl-pyrrolidin-3-yl)-methyl-carbamoyl]-pyrrolidin-3-yl}-methyl-carbamic acid tert-butyl ester 
• 169749-99-9 (3S)-(-)-1-benzyl-3-(methylamino)pyrrolidine 

Downstream Products

• 762286-17-9 (S)-3-Methylamino-pyrrolidine-1-carboxylic acid [(S)-1-(4,4-dimethyl-cyclohexyl)-pyrrolidin-3-yl]-methyl-amide 

Relevant articles and documents

Bis(aminopyrrolidine)-derived ureas (APUs) as potent MCH1 receptor antagonists

Ureas derived from two substituted 3-aminopyrrolidine subunits were prepared as constrained analogs of a linear lead compound and tested as antagonists of the MCH1 receptor. The series was optimized for substitution and stereochemistry to generate a functional antagonist with a Ki of 3.3 nM and IC50 of 12 nM (GTPγS).