762286-17-9Relevant articles and documents
Bis(aminopyrrolidine)-derived ureas (APUs) as potent MCH1 receptor antagonists
Grey, Jonathan,Dyck, Brian,Rowbottom, Martin W.,Tamiya, Junko,Vickers, Troy D.,Zhang, Mingzhu,Zhao, Liren,Heise, Christopher E.,Schwarz, David,Saunders, John,Goodfellow, Val S.
, p. 999 - 1004 (2007/10/03)
Ureas derived from two substituted 3-aminopyrrolidine subunits were prepared as constrained analogs of a linear lead compound and tested as antagonists of the MCH1 receptor. The series was optimized for substitution and stereochemistry to generate a functional antagonist with a Ki of 3.3 nM and IC50 of 12 nM (GTPγS).