76237-19-9Relevant academic research and scientific papers
SYNTHESIS AND REACTIONS OF PYRROLOAZEPINE DERIVATIVES
Glushkov, R. G.,Stezhko, T. V.
, p. 853 - 856 (1980)
The construction of the pyrroloazepine system by the reaction of 2-oxo-3-hydroxy-4-cyano-2H,1,5,6,7-tetrahydroazepine with glycine ester and subsequent cyclization of the resulting N-substituted amino nitrile in an alcohol solution of sodium ethoxide was studied.The pyrroloazepine system was converted to the three-ring pyrimidopyrroloazepine system, the alkylation of which gave N,N-dialkyl and N,N,N-trialkyl derivatives.Cyclization of 3-benzyl-4,6-dioxo-5-aminoethyl-6H,3,4,7,8,9,10-hexahydropyrimidopyrroloazepine hydrochloride under the influence of phosphorus oxychloride gave the four-ring pyrazinoazepinopyrrolo-pyrimidine system.The structures of the compounds obtained were confirmed by their IR, UV, and PMR spectra.
