SYNTHESIS AND REACTIONS OF PYRROLOAZEPINE DERIVATIVES

Article abstract of DOI:10.1007/BF00513170

The construction of the pyrrolo<2,3-c>azepine system by the reaction of 2-oxo-3-hydroxy-4-cyano-2H,1,5,6,7-tetrahydroazepine with glycine ester and subsequent cyclization of the resulting N-substituted amino nitrile in an alcohol solution of sodium ethoxide was studied.The pyrrolo<2,3-c>azepine system was converted to the three-ring pyrimido<4',5':4,5>pyrrolo<2,3-c>azepine system, the alkylation of which gave N,N-dialkyl and N,N,N-trialkyl derivatives.Cyclization of 3-benzyl-4,6-dioxo-5-aminoethyl-6H,3,4,7,8,9,10-hexahydropyrimido<4',5':4,5>pyrrolo<2,3-c>azepine hydrochloride under the influence of phosphorus oxychloride gave the four-ring pyrazino<3,2,1-b,c>azepino<3,4-b>pyrrolo<3,2-d>-pyrimidine system.The structures of the compounds obtained were confirmed by their IR, UV, and PMR spectra.