7624-95-5Relevant academic research and scientific papers
Cinnoline derivatives as human neutrophil elastase inhibitors
Giovannoni, Maria Paola,Schepetkin, Igor A.,Crocetti, Letizia,Ciciani, Giovanna,Cilibrizzi, Agostino,Guerrini, Gabriella,Khlebnikov, Andrei I.,Quinn, Mark T.,Vergelli, Claudia
, p. 628 - 639 (2016)
Compounds that can effectively inhibit the proteolytic activity of human neutrophil elastase (HNE) represent promising therapeutics for treatment of inflammatory diseases. We present here the synthesis, structure-activity relationship analysis, and biolog
Acid-Promoted Bicyclization of Diaryl Alkynes: Synthesis of 2 H-Indazoles with in Situ Generated Diazonium Salt as Nitrogen Source
Zhang, Cheng,Chang, Sailan,Dong, Shanliang,Qiu, Lihua,Xu, Xinfang
, p. 9125 - 9136 (2018/06/22)
An unprecedented transition-metal-free tandem bicyclization of diaryl alkynes has been disclosed, which provides a streamlined access to a range of polycyclic 2H-indazoles in high to excellent yields. The salient features of this reaction include readily
A convenient and efficient protocol for the synthesis of 4(1H)-cinnolones, 1,4-dihydrocinnolines, and cinnolines in aqueous medium: Application for detection of nitrite ions
Dey, Raju,Ranu, Brindaban C.
, p. 8918 - 8924 (2011/11/30)
3-Aryl/alkyl-4(1H)-cinnolones are obtained in one step from 2-aryl/alkylethynyl aniline by reaction with sodium nitrite and dilute hydrochloric acid via Richter cyclization. The alkyl cinnolones on reduction with Sn/HCl furnish 1,4-dihydro-3-alkylcinnolin
Facile cyclization of 2-arylethynyl aniline to 4(1H)-cinnolones: A new chemodosimeter for nitrite ions
Dey, Raju,Chatterjee, Tanmay,Ranu, Brindaban C.
experimental part, p. 461 - 464 (2011/02/26)
2-Arylethynyl anilines undergo very fast reaction (5 min) with nitrite ions in aqueous acidic media to produce 4(1H)-cinnolones which exhibit yellow color and UV absorbance at 391 nm. This reaction is irreversible and has been successfully tested for the
Richter cyclization and co-cyclization reactions of triazene-masked diazonium ions
Goeminne, Annelies,Scammells, Peter J.,Devine, Shane M.,Flynn, Bernard L.
, p. 6882 - 6885 (2011/03/18)
The conventional Richter cyclization involves diazotization of 2-alkynylanilines with HX (aq) (X = Br or Cl) and NaNO2, followed by spontaneous ring closure to give a mixture of 4-halocinnoline and 4-cinnolinone products. The different products
Electrochemical transformation of 4-cyanocinnolines into 4(1H)-cinnolones
Matsubara,Matsuda,Kato,Yamaguchi,Yoshida
, p. 7901 - 7904 (2007/10/03)
Electrochemical transformation of 4-cyanocinnolines into 4(1H)-cinnolones has been achieved, for the first time, in 70 ~ 100% yield. (C) 2000 Elsevier Science Ltd.
