76244-39-8

Upstream product

• 504-29-0 2-aminopyridine 
• 1022-46-4 2-phenyl-4H-3,1-benzoxazin-4-one 
• 69589-64-6 2-benzoylamino-N-pyridin-2-yl-benzamide 
• 91804-58-9 3-(pyridin-2-yl)quinazolin-4(3H)-one 
• 65-85-0 benzoic acid 

Downstream Products

• 106756-15-4 RuCl₂(C₈H₄N₂O(C₆H₅)(C₅H₄N))2 
• 97912-43-1 Zn((C₆H₅)C₈H₄N₂O(C₅H₄N))(CH₃CO₂)2 
• 97912-44-2 Cd((C₆H₅)C₈H₄N₂O(C₅H₄N))(CH₃CO₂)2 
• 97912-40-8 Co((C₆H₅)C₈H₄N₂O(C₅H₄N))2(CH₃CO₂)2 
• 97912-42-0 Cu((C₆H₅)C₈H₄N₂O(C₅H₄N))2(CH₃CO₂)2 
• 97912-41-9 Ni((C₆H₅)C₈H₄N₂O(C₅H₄N))2Cl₂ 

Relevant academic research and scientific papers

Rh(I)-Catalyzed Direct C6?H Arylation of 2-Pyridones with Aryl Carboxylic Acids

A Rh(I)-catalyzed C6-selective C?H arylation of 2-pyridones with inexpensive, readily available, safe and structurally diverse aryl carboxylic acids with the aid of a pyridine directing group is developed. This decarbonylative arylation protocol features an easy-to-handle catalytic system, and is amenable to diversely substituted 2-pyridones and aryl carboxylic acids. It allows access to a wide range of C6-arylated 2-pyridones, including those that are difficult to prepare using conventional C?H arylation processes. The method tolerates various electron-neutral, electron-rich and electron-deficient functional groups, and affords the products in 41–91% yields. (Figure presented.).

An efficient synthesis of 2,3-diaryl (3H)-quinazolin-4-ones via imidoyl chlorides

A practical and efficient three step synthetic route to 2,3-diaryl (3H)-quinazolin-4-ones has been developed. The key step involves microwave-assisted condensation of an imidoyl chloride with an aryl amine. This methodology affords the products cleanly and in high yields.

Synthesis and anti-inflammatory activity of 2,3-diaryl-4(3H)-quinazolinones

2,3-Diaryl-4(3H)-quinazolinones containing various substituents on diaryl rings have been synthesized and evaluated for their cyclooxygenase-2 inhibitory activity by the colorimetric COX (ovine) inhibitor screening assay and anti-inflammatory activity by the carrageenan-induced rat paw edema assay. 2-(4-Nitrophenyl)-3-(4-tolyl)-4(3H)-quinazolinone showed a maximum COX-2 inhibition of 27.72% at 22 μM concentration in the present series and exhibited a mild anti-inflammatory activity at a dose of 50 mg/kg in carrageenan-induced rat paw edema assay.

Synthesis of Some New 2-Aryl-3-Hetaryl-4(3H) Quinazolones

2-Aryl (alkyl)-benzoxazin-4-ones (I, R = CH3, C6H5, C6H5CH2, p-NO2C6H4) are condensed with 2-amino hetaryls (pyridyl, pyrimidyl, thiazolyl), 1 and 2-amino anthraquinones, p-amino acetophenone and 1,2-diamines like ethylene diamine and o-phenylene diamine.The products are obtained in excellent yields and are characterised by infrared and elemental analysis.