7625-01-6

Basic information

• Product Name: ETHYL 3-METHYL-4H-1,4-BENZOTHIAZINE-2-CARBOXYLATE
• Synonyms: ETHYL 3-METHYL-4H-1,4-BENZOTHIAZINE-2-CARBOXYLATE;CHEMBRDG-BB 4009567;AKOS BBS-00002596;Ethylmethylbenzothiazinecarboxylate;3-methyl-4h-1,4-benzothiazine-2-carboxylic acid ethyl ester;ethyl 3-methyl-4H-1,4-benzothiazine-2-carboxylate(SALTDATA: FREE);ethyl 3-methyl-4H-benzo[b][1,4]thiazine-2-carboxylate
• CAS NO: 7625-01-6
• Molecular Formula: C₁₂H₁₃NO₂S
• Molecular Weight: 235.3
• Mol File: 7625-01-6.mol
• Article Data: 15

Chemical Properties

• Melting Point: 143 °C
• Boiling Point: 330.1°Cat760mmHg
• Flash Point: 153.4°C
• Appearance: /
• Density: 1.205g/cm³
• Vapor Pressure: 0.00017mmHg at 25°C
• Refractive Index: 1.582
• CAS DataBase Reference: ETHYL 3-METHYL-4H-1,4-BENZOTHIAZINE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 3-METHYL-4H-1,4-BENZOTHIAZINE-2-CARBOXYLATE(7625-01-6)
• EPA Substance Registry System: ETHYL 3-METHYL-4H-1,4-BENZOTHIAZINE-2-CARBOXYLATE(7625-01-6)

Safety Data

• Statements: 20/21/22
• Safety Statements: 26-36
• Hazardous Substances Data: 7625-01-6(Hazardous Substances Data)

Usage

General Description

ETHYL 3-METHYL-4H-1,4-BENZOTHIAZINE-2-CARBOXYLATE is a chemical compound with the molecular formula C12H13NO2S. It is a derivative of benzothiazine, containing an ethyl ester group and a carboxylate group. ETHYL 3-METHYL-4H-1,4-BENZOTHIAZINE-2-CARBOXYLATE is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has been studied for its potential biological activities, including anti-inflammatory and anti-cancer properties.ETHYL 3-METHYL-4H-1,4-BENZOTHIAZINE-2-CARBOXYLATE is an important compound with various potential applications in the field of medicine and agrochemistry.

InChI:InChI=1/C12H13NO2S/c1-3-15-12(14)11-8(2)13-9-6-4-5-7-10(9)16-11/h4-7,13H,3H2,1-2H3

Upstream product

• 6287-35-0 ethyl 3-anilinocrotonate 
• 1141-88-4 2-Aminophenyl disulfide 
• 923001-77-8 C₈H₁₆N₂O₂ 
• 5065-81-6 ethyl 3-(butylamino)but-2-enoate 
• 141-97-9 ethyl acetoacetate 
• 64-17-5 ethanol 
• 72324-39-1 5-acetyl-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 137-07-5 2-amino-benzenethiol 
• 67434-68-8 Ethyl acetoacetate 
• 57031-90-0 ethyl (Z)-3-hydroxy-2-butenoate 
• 66155-41-7 ethyl (2-methyl-2,3-dihydro-benzothiazol-2-yl)-acetate 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 

Downstream Products

• 169058-58-6 C₁₈H₁₆N₄OS₂ 
• 169058-57-5 C₁₈H₁₆N₄S₂ 
• 169058-56-4 C₁₇H₁₃BrN₄S₂ 
• 169058-55-3 C₁₇H₁₃ClN₄S₂ 
• 169058-54-2 C₁₇H₁₄N₄S₂ 
• 169058-47-3 C₁₀H₁₁N₃OS 
• 169058-87-1 C₁₉H₁₇ClN₄O₂S 
• 169058-75-7 C₁₈H₁₆N₄O₂S 
• 169058-74-6 C₁₈H₁₆N₄OS 
• 169058-73-5 C₁₇H₁₃BrN₄OS 
• 169058-72-4 C₁₇H₁₃ClN₄OS 
• 169058-71-3 C₁₇H₁₄N₄OS 
• 169059-19-2 C₁₉H₁₉ClN₄O₂S₂ 
• 169059-07-8 C₁₈H₁₈N₄O₂S₂ 

Relevant articles and documents

Graphene oxide (GO): An efficient carbocatalyst for the benign synthesis of functionalized 1,4-benzothiazines

Graphene oxide (GO) has been found to be highly efficient and recyclable carbocatalyst for the benign construction of heterocyclic molecule 1,4-benzothiazine from 2-aminothiophenol and 1,3-dicarbonyl compound. A vast range of highly functionalized 1,4-ben

A facile and green synthesis of "5-(3-methyl-7-substituted-4H-1, 4-benzothiazin-2-yl)-4-aryl-4H-1, 2, 4-triazole-3-thiols" under ultrasound irradiation

A series of novel 3-methyl-7-substituted-4H-1, 4-benzothiazine-2- carbohydrazide & corresponding thiosemicarbazide have been synthesized. The 1, 4-benzothiazine thiosemicarbazides i.e. 2-[(3-methyl-7-substituted-4H-1, 4-benzothiazin-2-yl) carbonyl]-N-aryl-hydrazine carbothiamide when cyclised with 2N sodium hydroxide via intramolecular dehydrative cyclisation gave benzothiazonyl triazoles. The given procedure is in 4-steps. The final step is an intramolecular cyclisation is achieved by ultrasound irradiation & also by conventional method. In general, substantial improvement in rates and increase in modest yields observed when reactions are carried out under sonication, compared with classical heating method. The structures of these compounds have been elucidated by spectral (IR, 1H NMR) analysis.

Synthesis and antimicrobial activity of morpholinyl/ piperazinylbenzothiazines

Structurally diverse morpholinyl/piperazinylbenzothiazines have been synthesized in quantitative yields by the reaction of substituted 1,4-benzothiazines with morpholine/N-(2-hydroxyethyl)piperazine. 1,4-Benzothiazines were prepared by the reaction of substituted 2-aminobenzenethiols with b-ketoesters. The structures of the synthesized compounds were confirmed by their analytical and spectroscopic data. The synthesized compounds were evaluated for their antimicrobial activity against bacterial species; E. coli and Bacillus cereus. Some of the synthesized compounds have shown significant activity against microorganisms.