76259-25-1

Upstream product

• 64310-32-3 1-(4-chlorobenzoyl)thiosemicarbazide 
• 122-01-0 4-chloro-benzoyl chloride 
• 26028-65-9 5-(4-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione 
• 76259-22-8 (chloro-4 phenyl)-2 thiazolo<3,2-b>-s-triazole-6 acetate d'ethyle 

Relevant academic research and scientific papers

Thiazole triazole-6-acetamide derivative and application

The invention discloses a thiazole [3,2-b] [1,2,4]-triazole-6-acetamide derivative as shown in formula I or a pharmaceutically acceptable hydrate and salt thereof. The derivative comprises a stereisomer or tautomer thereof; R1 in the formula I is hydrogen, methyl, halogen, hydroxy, methoxy group, acetyl, propionyl, nitro or alkoxy; R2 and R3 are independently selected from C1-C6 alkyl or R2 and R3 and nitrogen atoms connected with the R2 and R3 are formed into pyrryl, piperidyl, morpholinyl, N-methyl piperazine and N-phenylpiperazine. The thiazole [3,2-b] [1,2,4]-triazole-6-acetamide derivative disclosed by the invention has an obvious restraining function to acetylcholin esterase and is used for enhancing the memory of the patients suffering from dementia and Alzheimer's disease. The invention also relates to a preparation method of the compound and application of the compound for preparing the drug for treating the senile dementia.

Sur la synthese d'acides thiazolotriazolylacetiques

During the synthesis of thiazolotriazolylacetic acids, the condensation of ethyl 4-chloro-3-oxobutyrate with triazolinethiones was studied.The use of an alkaline reagent (triethylamine) leads only to S-alkylation and not to the expected cyclized product.T