76271-74-4

Usage

Uses

Used in Pharmaceutical Industry:
2-((tert-Butyldiphenylsilyl)oxy)acetic acid is used as an intermediate in the synthesis of N-Desmethyl-N-hydroxymethyl Tebuthiuron (D295445), a metabolite of the nonselective broad-spectrum herbicide Tebuthiuron (T013620). This application is crucial for the development of effective herbicides that can control a wide range of unwanted plant species, thereby improving agricultural productivity and crop quality.
In the synthesis process, 2-((tert-Butyldiphenylsilyl)oxy)acetic acid plays a vital role in the formation of the desired product, N-Desmethyl-N-hydroxymethyl Tebuthiuron, through a series of chemical reactions. The tert-butyldiphenylsilyl group in the molecule provides steric hindrance and electronic effects that facilitate the desired transformation, making it an essential component in the synthesis pathway.
Overall, 2-((tert-Butyldiphenylsilyl)oxy)acetic acid is a valuable chemical intermediate with applications in the pharmaceutical industry, particularly in the development of herbicides. Its unique structural features and reactivity make it an important building block in the synthesis of various chemical compounds, contributing to advancements in agriculture and other related fields.

Upstream product

• 79-14-1 glycolic Acid 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 154698-92-7 methyl 2-((tert-butyl(diphenyl)silyl)oxy)acetate 
• 441784-83-4 2-((tert-butyl(diphenyl)silyl)oxy)acetic acid ethyl ester 
• 115869-43-7 (tert-butyldiphenylsilanyloxy)acetaldehyde 

Downstream Products

• 133323-17-8 (E)-1-(Dimethylphenylsilyl)-1-buten-3-ol ((tert-Butyl-diphenylsilyl)oxy)acetate 
• 133323-32-7 (E)-1-(tert-Butyldiphenylsilyl)-1-buten-3-ol ((tert-Butyldiphenylsilyl)oxy)acetate 
• 139888-76-9 t-butyldiphenylsiloxymethyl isocyanate 
• 182414-58-0 (5S,6S)-6-{(R)-1-[2-(tert-Butyl-diphenyl-silanyloxy)-acetoxy]-ethyl}-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid allyl ester 
• 1026031-64-0 2-(tert-Butyl-diphenyl-silanyloxy)-N-[2-(4-iodo-1H-indol-3-yl)-2-oxo-ethyl]-acetamide 
• 321527-28-0 N-[2-(4-bromo-1H-indol-3-yl)-ethyl]-2-(tert-butyl-diphenyl-silanyloxy)-acetamide 
• 496975-21-4 1,2:4,5-di-O-isopropylidene-β-D-fructopyranos-3-yl (tert-butyldiphenylsilyloxy)acetate 
• 405519-78-0 4-bromo-3-[2-(tert-butyl-diphenyl-silanyloxymethyl)-oxazol-5-yl]-1-methoxymethyl-1H-indole 
• 761433-60-7 1-benzyl-4-bromo-3-[2-(tert-butyl-diphenyl-silanyloxymethyl)-oxazol-5-yl]-1H-indole 
• 761433-65-2 4-bromo-3-[2-(tert-butyl-diphenyl-silanyloxymethyl)-oxazol-5-yl]-indole-1-carboxylic acid tert-butyl ester 
• 761433-67-4 4-bromo-3-[2-(tert-butyl-diphenyl-silanyloxymethyl)-oxazol-5-yl]-1-(toluene-4-sulfonyl)-1H-indole 

Relevant academic research and scientific papers

Fullerene derivatives as dual inhibitors of HIV-1 reverse transcriptase and protease

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NOVEL METHODS OF USING NITRIC OXIDE DONOR COMPOUNDS FOR TREATMENT OF COVID-19 AND OTHER INFECTIOUS DISEASES

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AZETIDIN-3-YLMETHANOL DERIVATIVES AS CCR6 RECEPTOR MODULATORS

The present invention relates to compounds of Formula (I), their synthesis and use as CCR6 receptor modulators for the treatment or prevention of various diseases, conditions or disorders.

COMPOUNDS AND METHODS FOR THE TREATMENT OF OCULAR DISORDERS

Described herein are compositions and methods for the treatment of ocular surface disorders including meibomian gland dysfunction, blepharitis, dry eye disease and other inflammatory/ infections disease of the anterior surface of the eye. Said compositions and methods comprise keratolytic conjugate which demonstrate keratolytic activity, and anti-inflammatory or other desirable activities. Topical administration of said compositions to the eye, ocular surface or surrounding areas provides therapeutic benefit to patients suffering from ocular surface disorders.

Direct anti Glycolate Aldol Reaction of Protected Chiral N-Hydroxyacetyl Thiazolidinethiones with Acetals Catalyzed by a Nickel(II) Complex

The direct and stereocontrolled addition of (S)-4-isopropyl-N-(2-pivaloyloxyacetyl)-1,3-thiazolidine-2-thione to dialkyl acetals of aromatic and α,β-unsaturated aldehydes catalyzed by 2.5–5 mol-% of a nickel(II) complex permits the synthesis of diastereom

Cyclodextrin derivative inclusion compound for treating pancreatic cancer

The invention relates to a cyclodextrin derivative inclusion compound for treating the pancreatic cancer. The existing ways of two active ingredients in the inclusion compound are different, wherein gemcitabine is bonded to a beta-cyclodextrin derivative in a chemical bonding mode first, and then the beta-cyclodextrin derivative further includes erlotinib to form a drug-loaded inclusion compound.Compared with a conventional cyclodextrin inclusion compound, and the beta-cyclodextrin derivative inclusion compound can constantly release the erlotinib and the gemcitabine in the body, so that theerlotinib and the gemcitabine maintain within the effective effect concentration range in the blood for a long time. Therefore, by means of the beta-cyclodextrin derivative inclusion compound, the drug combination curative effect can be obviously improved, and an unexpected excellent effect is generated.

Biomimetic synthesis, antibacterial activity and structure-activity properties of the pyroglutamate core of oxazolomycin

Biomimetic intramolecular aldol reactions on oxazolidine templates derived from serine may be used to generate densely functionalised pyroglutamates, which are simpler mimics of the right hand side of oxazolomycin. Some of the compounds from this sequence exhibit in vivo activity against S. aureus and E. coli, suggesting that pyroglutamate scaffolds may be useful templates for the development of novel antibacterials, and cheminformatic analysis has been used to provide some structure-activity data.

An efficient synthesis of the precursor of AI-2, the signalling molecule for inter-species quorum sensing

Autoinducer-2 (AI-2) is a signalling molecule for bacterial inter-species communication. A synthesis of (S)-4,5-dihydroxypentane-2,3-dione (DPD), the precursor of AI-2, is described starting from methyl glycolate. The key step was an asymmetric reduction of a ketone with (S)-Alpine borane. This new method was highly reproducible affording DPD for biological tests without contaminants. The biological activity was tested with the previously available assays and compared with a new method using an Escherichia coli reporter strain thus avoiding the use of the pathogenic Salmonella reporter.

New insights into poly(lactic- co -glycolic acid) microstructure: Using repeating sequence copolymers to decipher complex NMR and thermal behavior

Sequence, which Nature uses to spectacular advantage, has not been fully exploited in synthetic copolymers. To investigate the effect of sequence and stereosequence on the physical properties of copolymers, a family of complex isotactic, syndiotactic, and atactic repeating sequence poly(lactic-co-glycolic acid) copolymers (RSC PLGAs) were prepared and their NMR and thermal behavior was studied. The unique suitability of polymers prepared from the bioassimilable lactic and glycolic acid monomers for biomedical applications makes them ideal candidates for this type of sequence engineering. Polymers with repeating units of LG, GLG and LLG (L = lactic, G = glycolic) with controlled and varied tacticities were synthesized by assembly of sequence-specific, stereopure dimeric, trimeric, and hexameric segmer units. Specifically labeled deuterated lactic and glycolic acid segmers were likewise prepared and polymerized. Molecular weights for the copolymers were in the range Mn = 12-40 kDa by size exclusion chromatography in THF. Although the effects of sequence-influenced solution conformation were visible in all resonances of the 1H and 13C NMR spectra, the diastereotopic methylene resonances in the 1H NMR (CDCl3) for the glycolic units of the copolymers proved most sensitive. An octad level of resolution, which corresponds to an astounding 31-atom distance between the most separated stereocenters, was observed in some mixed sequence polymers. Importantly, the level of sensitivity of a particular NMR resonance to small differences in sequence was found to depend on the sequence itself. Thermal properties were also correlated with sequence.

Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors

The present invention provides a compound of formula (1) wherein R1-R5, R25, R26, Y and X2 are defined as in claim 1. The compounds activate human peroxisome proliferator activated receptors (hPPARs) and arc useful for the treatment of associated disorders such as cardiovascular disease and hypercholesteremia.