76279-28-2

Usage

Uses

Used in Research Applications:
α-ethylmescaline is used as a research chemical for studying the effects of psychoactive substances on the human brain and their potential therapeutic applications. Its unique properties allow researchers to explore the mechanisms of hallucinations and altered states of consciousness.
Used in Controlled Substances Regulation:
Due to its psychoactive effects and potential for abuse, α-ethylmescaline is considered a controlled substance and is regulated in many countries. This regulation helps to prevent misuse and ensure that the compound is used responsibly and within the confines of the law.

Upstream product

• 128113-78-0 <(S)-1-(2,5-dimethoxyphenyl)ethyl><(S)-1-phenylethyl>amine 
• 1201-38-3 2',5'-dimethoxyacetophenone 

Downstream Products

• 128113-97-3 N-[(S)-1-(2,5-Dimethoxy-phenyl)-ethyl]-N-(2,4-dinitro-phenylsulfanyl)-4-methyl-benzenesulfonamide 
• 128113-78-0 <(S)-1-(2,5-dimethoxyphenyl)ethyl><(S)-1-phenylethyl>amine 

Relevant academic research and scientific papers

Design, synthesis, and optical resolution of a novel non-natural chiral auxiliary, 1-(2,5-dimethoxyphenyl)ethylamine. Application to diastereoselective alkylation of aldimines

A chiral amine; 1-(2,5-dimethoxyphenyl)ethylamine, was found to be an effective chiral auxiliary for the diastereoselective alkylation of its aldimines with alkylmetals. The 1-(2,5-dimethoxyphenyl)ethyl group of the chiral auxiliary could be removed by the acetylation and then oxidation of the resultant alkylated product, accompanying an amino-transfer from the chiral auxiliary to the final product. Racemic 1-(2,5- dimethoxyphenyl)ethylamine could be easily synthesized from 1,4- dimethoxybenzene and resolved by the diastereomeric salt formation with mandelic acid to give both enantiomers in pure forms.

Chiral Building Blocks for the Synthesis of Nitrogen-Containing Natural Products, 5. The Enantioselective Synthesis of Optically Active, Benzene Nucleus-Substituted 1-Phenylethylamines from the Corresponding Acetophenones

An efficient two-step procedure for the synthesis of enantiomerically pure, benzene nucleus-substituted 1-phenylethylamines 1 is described, with predictable absolute configuration at the stereogenic center: Imine formation from the substituted acetophenones 6 with (S)- or (R)-1-phenylethylamine and subsequent hydrogenation of the resulting Schiff bases 8 over Raney nickel leads to the secondary amines 9 and 10 in high diastereoselectivities.These dibenzylamines are cleaved regioselectively, usually next to the less substituted aromatic ring, giving the desired chiral 1-phenylethylamines 1 in high yields and enantiomeric purities.Scope and limitations of this new and facile approach to the versatile building blocks 1 are reported.