76284-87-2

Usage

Chemical composition

Consists of a benzooxazole core with a 4-bromophenylmethyl substituent.

Usage

Serves as a pharmaceutical intermediate, research chemical, and building block for the synthesis of other compounds.

Structure and properties

Makes it suitable for use as a fluorescent probe in biological studies and as a component in the development of new materials.

Potential applications

Has potential applications in the field of organic electronics and photonics due to its electronic and optical properties.

Handling precautions

Should be handled with caution due to potential hazards and reactivity.

InChI:InChI=1/C14H10BrNO/c15-11-7-5-10(6-8-11)9-14-16-12-3-1-2-4-13(12)17-14/h1-8H,9H2

Upstream product

• 76284-86-1 2-(4-Bromo-phenyl)-acetimidic acid methyl ester; hydrochloride 
• 95-55-6 2-amino-phenol 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 934-94-1 1-bromo-4-bromoethynyl-benzene 
• 136350-66-8 1-bromo-4-(2,2-dibromovinyl)benzene 
• 615-18-9 2-chloro-1,3-benzoxazole 
• 17095-20-4 p-<(trimethylsilyl)methyl>bromobenzene 
• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 931611-48-2 C₁₄H₁₂BrNO₂ 
• 37859-24-8 2-(4-bromophenyl)acetyl chloride 
• 16532-79-9 4-Bromophenylacetonitrile 

Downstream Products

• 1396008-52-8 2-(4-(benzo[d]oxazol-2-ylmethyl)phenethyl)-4,6-dihydroxybenzoic acid 
• 1396008-49-3 2-(4-ethynylbenzyl)benzo[d]oxazole 
• 1414627-40-9 benzyl 2-((4-(benzo[d]oxazol-2-ylmethyl)phenyl)ethynyl)-4,6-bis(benzyloxy)benzoate 

Relevant academic research and scientific papers

Elemental Sulfur-Promoted Benzoxazole/Benzothiazole Formation Using a C=C Double Bond as a One-Carbon Donator

An efficient method to assemble diverse benzoxazoles/benzothiazoles in good yields was developed via oxidative cyclization with 2-aminothiophenols or 2-iodoanilines as raw materials. In this protocol, elemental sulfur was used as the effective oxidant and C atoms on the C=C double bond were introduced as a one-carbon donator.

Lewis Basic Salt-Promoted Organosilane Coupling Reactions with Aromatic Electrophiles

Lewis basic salts promote benzyltrimethylsilane coupling with (hetero)aryl nitriles, sulfones, and chlorides as a new route to 1,1-diarylalkanes. This method combines the substrate modularity and selectivity characteristic of cross-coupling with the practicality of a base-promoted protocol. In addition, a Lewis base strategy enables a complementary scope to existing methods, employs stable and easily prepared organosilanes, and achieves selective arylation in the presence of acidic functional groups. The utility of this method is demonstrated by the synthesis of pharmaceutical analogues and its use in multicomponent reactions.

Anacardic acid derived salicylates are inhibitors or activators of lipoxygenases

Lipoxygenases catalyze the oxidation of unsaturated fatty acids, such as linoleic acid, which play a crucial role in inflammatory responses. Selective inhibitors may provide a new therapeutic approach for inflammatory diseases. In this study, we describe

Synthesis of heteroaryl ketones via tandem reaction of 1,1-dibromoethenes

A novel method for the synthesis of heteroaryl ketones through one-pot tandem reaction of 1,1-dibromoethenes with 2-amino(thio)phenols promoted by TBAF·3H2O and RuCl3(5%)/air was developed. This novel method includes several reactions in one-pot and utilizes economical yet efficient reagents to generate synthetically and biologically interesting heteroaryl ketones under mild conditions with good efficiency.

Aminobenzoxazoles as therapeutic agents

A compound of Formula (I), wherein the substituents are as defined herein, which are useful as kinase inhibitors.

Synthesis and characteristics of novel poly (Terphenylenevinylene) derivative containing benzoxazolyl group

Poly( l ,4-pheny lene-2 ' -methoxy-5'-ethylhcxyl-1' ,4'-phenylene-1″ ,4″ phenylene-α-benzoxazolylvinylene) (PTPBOV) was synthesized through the Suzuki reaction of diboronic acid and dibromide and following end-capping reaction. The electron affinity level