76285-79-5

Basic information

• Product Name: 4-(p-acetoxyphenyl)-3-benzyl-7-methoxychroman
• CAS NO: 76285-79-5
• Molecular Weight: 388.463
• Mol File: 76285-79-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(p-acetoxyphenyl)-3-benzyl-7-methoxychroman(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(p-acetoxyphenyl)-3-benzyl-7-methoxychroman(76285-79-5)
• EPA Substance Registry System: 4-(p-acetoxyphenyl)-3-benzyl-7-methoxychroman(76285-79-5)

Safety Data

• Hazardous Substances Data: 76285-79-5(Hazardous Substances Data)

Upstream product

• 42327-52-6 7-methoxy-chroman-4-one 
• 30779-91-0 (3E)-2,3-dihydro-7-methoxy-3-(phenylmethylene)-4H-1-benzopyran-4-one 
• 76285-73-9 3-benzyl-7-methoxy-4-chromanone 
• 76285-75-1 3-benzyl-7-methoxy-4-chromanol 
• 49855-03-0 3-(3-methoxyphenoxy)propionic acid 
• 6279-84-1 β-(m-methoxyphenoxy)propionitrile 
• 150-19-6 O-methylresorcine 
• 108-24-7 acetic anhydride 
• 76285-77-3 4-(p-hydroxyphenyl)-3-benzyl-7-methoxychroman 

Relevant articles and documents

Studies in Antifertility Agents: Part XXIX - synthesis of 4--3-benzylchromans

7-H/Methoxy-4-chromanones (1, 2), obtained by PPA cyclization of the respective β-aryloxypropionic acids, on treatment with araldehydes (3, 4) give the corresponding 3-arylidene-4-chromanones (5, 6).Catalytic hydrogenation of 5 and 6 over Pd-C (10percent) with one mole of hydrogen affords 3-benzyl-4-chromanones (7, 8), while hydrogenation of 6 yields 3-benzyl-7-methoxychroman (9).NaBH4 reduction of 7 and 8 gives the corresponding 4-chromanols (10, 11) as a mixture of 3,4-cis- and -trans-isomers, which are arylated as such with PhOH-AlCl3 to give 4-(p-hydroxyphenyl)chromans(12, 13) as the main products.Treatment of 12 and 13 with Ac2O-pyridine and with p-NO2C6H4COCl-pyridine yields the corresponding p-acetoxy (14, 15) and p-nitrobenzoyloxy (16, 17) derivatives.Alkylation of 12 and 13 with N-(β-chloroethyl)pyrrolidine hydrochloride furnishes the title compounds, 4--3-(p-chloro/H)benzyl-7-H/methoxy-chromans (18, 19).None of these compounds prevents pregnancy at 5 mg/kg dose in rats.