76292-70-1

Upstream product

• 13433-00-6 diethyl aminomalonate hydrochloride 
• 555-16-8 4-nitrobenzaldehdye 
• 20538-21-0 α,α-diphenylindole-2-methanol 
• 6829-40-9 aminomalonic acid diethyl ester 

Downstream Products

• 125660-73-3 (+/-)-rel-(1R,4S,5R)-diethyl 4-(4'-nitrophenyl)-3-aza-6,8-dioxo-7-oxabicyclo<3.3.0>octane-2,2-dicarboxylate 
• 125660-74-4 tetraethyl 5-(4'-nitrophenyl)-1,2,4-triazolidine-1,2,3,3-tetracarboxylate 
• 125713-11-3 3-(4-Nitro-phenyl)-4,6-dioxo-5-phenyl-hexahydro-pyrrolo[3,4-c]pyrrole-1,1-dicarboxylic acid diethyl ester 

Relevant academic research and scientific papers

Catalytic Enantioselective and Regioselective [3+3] Cycloadditions Using 2-Indolylmethanols as 3 C Building Blocks

The first catalytic asymmetric cycloaddition using 2-indolylmethanols as 3C building blocks has been established by a chiral phosphoric acid-catalyzed enantioselective and regioselective [3+3] cycloaddition of 2-indolylmethanols with azomethine ylides, which constructed biologically important tetrahydro-γ-carboline frameworks in high yields and excellent enantioselectivities (up to 83 % yield, 99:1 e.r.). This reaction not only represents the first application of 2-indolylmethanols as 3C building blocks in catalytic asymmetric cycloadditions, but also has established an abnormal regioselectivity in indolylmethanol-involved transformations.

X=Y-ZH COMPOUNDS AS POTENTIAL 1,3-DIPOLES. PART 24. PREPARATION AND THERMAL FRAGMENTATION OF IMIDAZOLIDINES. INFLUENCE OF METAL SALTS ON PYRROLIDINE VERSUS IMIDAZOLIDINE FORMATION

Imines of diethyl aminomalonates slowly dimerise to imidazolidines in ethanol or methylene chloride at 40 deg C, but cycloaddition to other imines does not occur.Imines of glycine, alanine and phenylglycine methyl esters undergo rapid regio- and stereo-sp

PREPARATION AND THERMAL FRAGMENTATION OF IMIDAZOLIDINES DERIVED FROM ARYL IMINES

Aryl imines of diethyl aminomalonate undergo facile dimerisation to imidazolidines.Heating the imidazolidines at 110 deg C in the presence of N-phenyl maleimide or diethyl azodicarboxylate gives pyrrolidines and triazolidines respectively via a retro 1,3-dipolar cycloaddition.