763-11-1

Upstream product

• 10305-43-8 butylsulfamoyl chloride 
• 109-73-9 N-butylamine 

Downstream Products

• 1744-71-4 N,N′-dibutylhydrazine 
• 3488-39-9 N-n-Butyl-N'-cyclohexylsulfamide 

Relevant academic research and scientific papers

The Zeolite ZSM-5-SO3H as an Effcient Mild Heterogeneous Catalyst for the Synthesis of 1,2,5-Thiadiazolidines, 1,2,6-Thiadiazines, and Benzo[d][1,2,7] thiadiazepines Under Microwave-assisted Solvent-free Conditions

Three series of compounds namely,1,2,5-thiadiazolidine-3,4(H)-dione-1,1-dioxydes, 1,2,6-thiadiazine-3,5(H)-dione-1,1-dioxydes, and benzo[d][1,2,7]thiadiazepine-1,5(2H)-dione-3,3-dioxydes have been synthesized by the acylation of N,N’-disubstituted symmetric sulfamides with oxalyl chloride, malonyl chloride, and phthaloyl chloride, respectively. These compounds were prepared under conventional and microwave-assisted solvent-free reaction conditions using the zeolite ZSM-5-SO3H as catalyst.

Microwave-assisted synthesis of some substituted sulfamides

Microwave-assisted synthesis of some substituted open-chain and cyclic sulfamides, by amine-exchange reaction, was studied in a modified domestic microwave oven. Reaction times and yields under microwave radiation were compared with classical heating. Synthesis of the sulfamides under microwave irradiation gave better yields with the desired compounds, and in considerably reduced reaction times, than those obtained by classical heating. [Supplementary materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfer, and Silicon and the Related Elements for the following free supplemental files: Additional figures.]

Hypervalent iodine reagent mediated diamination of [60]fullerene with sulfamides or phosphoryl diamides

A hypervalent iodine-promoted intermolecular diamination reactions of C60 with sulfamides or phosphoryl diamides affords two classes of novel C60-fused cyclic sulfamide or phosphoryl diamide derivatives. The reaction between C60 and sulfamides can be effectively controlled to selectively synthesize diamination products or azafulleroids under PhIO/I2 or PhI(OAc)2/I2 conditions, respectively. Moreover, phosphoryl diamides were first used as an amine source in the diamination of alkenes.

Inhibition pattern of sulfamide-related compounds in binding to carbonic anhydrase isoforms I, II, VII, XII and XIV

A set of sulfamides and sulfamates were synthesized and tested against several isoforms of carbonic anhydrase: CA I, CA II, CA VII, CA XII and CA XIV. The biological assays showed a broad range of inhibitory activity, and interesting results were found for several compounds in terms of activity (Ki 1 μm) and selectivity: some aromatic sulfamides are active against CA I, CA II and/or CA VII; while they are less active in CA XII and CA XIV. On the other hand, bulky sulfamides are selective to CA VII. To understand the origin of the different inhibitory activity against each isozyme we used molecular modeling techniques such as docking and molecular dynamic simulations.

3D-QSAR design of novel antiepileptic sulfamides

A three-dimensional quantitative structure-activity relationship method, the comparative molecular field analysis (CoMFA), was applied to design new anticonvulsant symmetric sulfamides. The training set (27 structures) was comprised by traditional and new-generation anticonvulsant (AC) ligands that exhibit a potent activity in MES test. Physicochemical determinants of binding, such as steric and electrostatic properties, were mapped onto the molecular structures of the set, in order to interpret graphically the CoMFA results in terms of field contribution maps. The 3D-QSAR models demonstrate a good ability to predict the activity of the designed compounds (r2 = 0.967, q2 = 0.756).

KINETICS OF OXIDATIVE SULFONATION OF BUTYLAMINE BY SULFUR DIOXIDE IN PRESENCE OF OXYGEN.

It is shown that N,N prime -dibutylsulfamide is formed by the reaction of sulfur dioxide with butylamine in presence of CuCl//2. The influence of all the components of the multicomponent system on the reaction rate was studied. It was found that oxygen inhibits oxidative sulfonation of butylamine: At high butylamine concentrations the reaction rate falls to a certain stationary value during the initial period. The reaction rate rises sharply at the end of the process.