7630-72-0Relevant academic research and scientific papers
New N-substituted (±)-dehydronorglaucine analogs
Benedetti-Doctorovich,Huang,Lambropoulos,Burgess,Zalkow
, p. 3701 - 3709 (1995)
The aporphine alkaloid N-carbethoxydehydronorglaucine (1) was found to have promising in vitro antitumor activity, but poor water solubility. We report the synthesis of 1, the efficient hydrolysis of its urethane group and the further transformation into several new dehydronorglaucine analogs.
PHOTOCHEMICAL SYNTHESIS OF APORPHINES: (+/-)-GLAUCINE, (+/-)-NORGLAUCINE AND (+/-)-DEHYDRONORGLAUCINE
Gupta, Sandeep,Bhakuni, Dewan S.
, p. 393 - 402 (2007/10/02)
Photochemical cyclization of 3 afforded 5, 4 and 8. 5 on LAH reduction furnished (+/-)-glaucine (6) and on treatment with ethanolic HCl afforded (+/-)-norglaucine (7). 10 obtained by the photocyclization of 9 was converted into 7 and 11 via 12.
OXIDATION OF APORPHINES BY TRIPLET BENZOPHENONE
Castedo, Luis,Iglesias, Teresa,Puga, Alberto,Saa, Jose M.,Suau, Rafael
, p. 915 - 918 (2007/10/02)
A mild and efficient method to dehydrogenate nonphenolic and phenolic aporphine and noraporphine alkaloids is described.It is based on the photoreduction of benzophenone by amines.
