New N-substituted (±)-dehydronorglaucine analogs

Article abstract of DOI:10.1080/00397919508015508

The aporphine alkaloid N-carbethoxydehydronorglaucine (1) was found to have promising in vitro antitumor activity, but poor water solubility. We report the synthesis of 1, the efficient hydrolysis of its urethane group and the further transformation into several new dehydronorglaucine analogs.

Full text of DOI:10.1080/00397919508015508

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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New N-Substituted (±)-
Dehydronorglaucine Analogs
a
a
Violeta Benedetti-Doctorovich , Fu-Yung Huang
,
a
a
John Lambropoulos , Edward M. Burgess & Leon
a
H. Zalkow
a
School of Chemistry and Biochemistry, Georgia
Institute of Technology , Atlanta, Ga, 30332-0400,
USA
Published online: 23 Sep 2006.
To cite this article: Violeta Benedetti-Doctorovich , Fu-Yung Huang , John
Lambropoulos , Edward M. Burgess & Leon H. Zalkow (1995) New N-Substituted (±)-
Dehydronorglaucine Analogs, Synthetic Communications: An International Journal
for Rapid Communication of Synthetic Organic Chemistry, 25:22, 3701-3709, DOI:
10.1080/00397919508015508
To link to this article: http://dx.doi.org/10.1080/00397919508015508
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