763024-93-7Relevant academic research and scientific papers
INHIBITORS OF JUN N-TERMINAL KINASE
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Page/Page column 101-102, (2010/08/18)
The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula (I): or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.
Potent and selective xanthine-based inhibitors of phosphodiesterase 5
Arnold, Nichola J.,Arnold, Ruth,Beer, David,Bhalay, Gurdip,Collingwood, Stephen P.,Craig, Sarah,Devereux, Nicholas,Dodds, Mark,Dunstan, Andrew R.,Fairhurst, Robin A.,Farr, David,Fullerton, Joseph D.,Glen, Angela,Gomez, Sylvie,Haberthuer, Sandra,Hatto, Julia D.I.,Howes, Colin,Jones, Darryl,Keller, Thomas H.,Leuenberger, Beate,Moser, Heinz E.,Muller, Irene,Naef, Reto,Nicklin, Paul A.,Sandham, David A.,Turner, Katharine L.,Tweed, Morris F.,Watson, Simon J.,Zurini, Mauro
, p. 2376 - 2379 (2007/10/03)
Inhibitors of PDE5 are useful therapeutic agents for treatment of erectile dysfunction. A series of novel xanthine derivatives has been identified as potent inhibitors of PDE5, with good levels of selectivity against other PDE isoforms, including PDE6. St
