76308-27-5Relevant articles and documents
Design and synthesis of trans-N-[4-[2-(6-cyano-1,2,3,4- tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB- 277011): A potent and selective dopamine D3 receptor antagonist with high oral bioavailability and CNS penetration
Stemp, Geoffrey,Ashmeade, Tracey,Branch, Clive L.,Hadley, Michael S.,Hunter, A. Jacqueline,Johnson, Christopher N.,Nash, David J.,Thewlis, Kevin M.,Vong, Antonio K. K.,Austin, Nigel E.,Jeffrey, Phillip,Avenell, Kim Y.,Boyfield, Izzy,Hagan, Jim J.,Middlemiss, Derek N.,Reavill, Charlie,Riley, Graham J.,Routledge, Carole,Wood, Martyn
, p. 1878 - 1885 (2000)
A selective dopamine D3 receptor antagonist offers the potential for an effective antipsychotic therapy, free of the serious side effects of currently available drugs. Using clearance and brain penetration studies as a screen, a series of 1,2,3