76310-73-1

Upstream product

• 76310-74-2 5-acetyl-2-ethoxybenzoic acid methyl ester 
• 16475-90-4 estere metilico dell'acido 5-acetilsalicilico 
• 497-19-8 sodium carbonate 
• 584-08-7 potassium carbonate 
• 75-03-6 ethyl iodide 

Downstream Products

• 1373428-01-3 methyl 5-(2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)acetyl)-2-(ethoxy)benzoate 
• 1373428-10-4 5-(2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)acetyl)-2-(ethoxy)benzoic acid 

Relevant academic research and scientific papers

Synthesis and bioactivity of substituted benzoylguanidine derivatives as potent Na+/H+ exchanger inhibitors

A novel series of substituted benzoylguanidine derivatives were designed and synthesized in order to evaluate their NHE1 inhibitory activity. Most of them were found to inhibit NHE1-mediated platelet swelling in a concentration-dependent manner, and eight compounds showed more potent NHE1 inhibitory activity than Cariporide. Compound 6f with an IC50 value of 1.08 × 10-10 molmiddot;L-1, was 39 times more potent than lead compound CPU-X-050420 in vitro tests. A novel series of 5-(2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)acetyl)benzoylguanidine derivatives 6a-6i have been synthesized and screened for their NHE1 inhibitory activity. Copyright

2-HYDROXY-5-(1-HYDROXY-2-PIPERAZINYLETHYL)-BENZOIC ACID DERIVATIVES

Derivatives of 2-hydroxy-5-(1-hydroxy-2-piperazinylethyl) benzoic acid are prepared which are useful for their blocking action on α and . beta.-adrenergic receptors. In addition, these compounds are useful as spasmolytic and antihypertensive agents.