763130-26-3

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 108-86-1 bromobenzene 
• 591-50-4 iodobenzene 
• 1694-22-0 (2Z)-2-(4-methoxyphenyl)-3-phenylacrylic acid 
• 104-54-1 3-Phenylpropenol 
• 696-62-8 para-iodoanisole 
• 103-54-8 cinnamyl acetate 
• 104-94-9 4-methoxy-aniline 
• 1504-58-1 3-Phenyl-2-propyn-1-ol 

Downstream Products

• 181421-22-7 (Z)-2-(4-methoxyphenyl)-3-phenylacrylaldehyde 

Relevant academic research and scientific papers

Hydrotalcite-supported palladium nanoparticles as catalysts for the hydroarylation of carbon-carbon multiple bonds

Palladium nanoparticles supported on Mg/Ca hydrotalcites catalyze the hydroarylation reaction of different alkynes and alkenes with aryl iodides under air in MeCN. The reaction of tertiary propargylic alcohols (1) with aryl iodides (2) yields, stereoselectively, γ,γ-diarylallylic alcohols (3) in moderate to high yields and high selectivity. Also, the HT/Pd hydroarylation reaction with aryl iodides was attempted on norbornene and α,β-unsaturated ketones affording, respectively, exo-aryl bicyclo[2.2.1]heptanes and β-aryl ketones in moderate to high yields. All the reactions described benefit from using a heterogeneous catalyst with evident advantages in terms of reaction purification and recyclability of the catalyst.

Chemo-, regio-, and stereoselective Heck-Matsuda arylation of allylic alcohols under mild conditions

Heck arylation with allylic alcohol is extremely challenging due to chemo-, regio-, and stereoselective scrambling. Here we report a mild protocol for the alcohol selective β- and α-arylation of allylic and cinnamyl alcohols respectively with aryldiazonium salts. The steric and electronic parameters of the alkene play a prominent role in the regioselectivity.

Palladium-catalyzed arylation of methyl 2-(acetoxymethyl)acrylate: A convenient synthesis of rearranged Morita-Baylis-Hillman acetates

Palladium-catalyzed arylation of methyl 2-(acetoxymethyl)acrylate with aryl iodides afforded the primary acetates of Morita-Baylis-Hillman adducts in good yields with high stereoselectivity under mild conditions (50°C).

Regio- and stereoselective heck α-arylation of cinnamyl alcohols

The Heck reaction of cinnamyl alcohols with aryl iodides has been investigated using n-Bu4NOAc as the base in toluene. Under these conditions, the reaction affords regio- and stereoselectively (Z)-2,3-diarylallylic alcohols in moderate to good yields. Experimental evidence suggests that the observed selectivity in formation of the vinylic substitution products is kinetic in origin under these conditions and that both the base and the solvent play a key role. Georg Thieme Verlag Stuttgart.

Palladium-catalyzed Heck arylations of allyl alcohols in ionic liquids: Remarkable base effect on the selectivity

Pd-catalyzed Heck arylation of allyl alcohols in tetraalkylammonium ionic liquids (ILs) can be made highly selective toward the formation of either aromatic carbonyl compounds or aromatic conjugated alcohols by carefully choosing both the IL and the base.

New route to o-terphenyls: Application to the synthesis of 6,7,10,11-tetramethoxy-2-(methoxycarbonyl)triphenylene

The hydroxy-o-terphenylcarboxylic acid esters 6a-f have been prepared by benzannulation of the 5,6-diaryl-3-methoxycarbonylhexa-3,5-dienoic acids 5a-f using triethylamine-ethyl chloroformate. The application of this new synthesis of triphenylenes is illus