76319-08-9

Upstream product

• 624-31-7 4-tolyl iodide 
• 65864-22-4 (S)-2-amino-3-phenylpropionamide hydrochloride 
• 201230-82-2 carbon monoxide 
• 21171-98-2 (2S)-2-amino-N-(4-methylphenyl)-3-phenylpropanamide 

Relevant academic research and scientific papers

Pd-Catalysed oxidative carbonylation of α-amino amides to hydantoins under mild conditions

The first example of palladium-catalysed oxidative carbonylation of unprotected α-amino amides to hydantoins is described here. The selective synthesis of the target compounds was achieved under mild conditions (1 atm of CO), without ligands and bases. The catalytic system overrode the common reaction pathway that usually leads instead to the formation of symmetrical ureas.