76322-25-3Relevant articles and documents
Rapid access to chroman-3-ones through gold-catalyzed oxidation of propargyl aryl ethers
Wang, Yanzhao,Ji, Kegong,Lan, Sylvester,Zhang, Liming
, p. 1915 - 1918 (2012/03/26)
The two-step: Chroman-3-ones are important intermediates for organic synthesis and medicinal chemistry. However, their syntheses require multiple steps and are not efficient. By using gold-catalyzed alkyne oxidation, this versatile heterocycle can be prepared in only two steps from readily available phenols and with mostly high efficiencies (see scheme).
6- and 8-Hydroxy-3,4-dihydro-3-(dipropylamino)-2H-1-benzopyrans. Dopamine Agonists with Autoreceptor Selectivity
Wise, Lawrence D.,DeWald, Horace A.,Hawkins, Elma S.,Reynolds, Donna M.,Heffner, Thomas G.,et al.
, p. 688 - 691 (2007/10/02)
The dopamine agonist profiles of 3,4-duhydro-3-(3-dipropylamino)-2H-1-benzopyran-6- and 8-ol (4 and 5, respectively) were examined.Both 4 and 5 exhibited greater relative affinity for receptors labeled with the dopamine agonist ligand propylnorapomorphine than for those labeled with the dopamine antagonist ligand haloperidol.Both compounds attenuated the simulation of brain dopamine synthesis caused by γ-butyrolactone (GBL) and decreased the firing rate of substantia nigra dopamine neurons in rats.This profile of activity, together with the ability of the dopamine antagonist haloperidol to reverse the inhibition of dopamine neuronal firing, indicate that both compounds are brain dopamine agonists.
Preparation of synthetic rotenoids
Verhe,De Kimpe,De Buyck,et al.
, p. 459 - 485 (2007/10/02)
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