76336-93-1

Upstream product

• 96-76-4 2,4-di-tert-Butylphenol 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 98-54-4 para-tert-butylphenol 
• 104-54-1 3-Phenylpropenol 
• 51167-54-5 4-t-butyl-2-cinnamyl phenol 
• 76336-92-0 6-(tert-butyl)-2-phenyl-2H-chromene 
• 76336-85-1 (2R,3S)-6-tert-Butyl-3-iodo-2-phenyl-chroman 

Relevant academic research and scientific papers

Selective synthesis of 6,8-di-t-butylated flavan over Zn-Al containing mesoporous silica catalysts

We demonstrate a much green synthesis method for highly selective synthesis of 6,8-di-t-butylated flavan (6,8-DTBF) by liquid phase alkylation of 2,4-di-t-butylphenol (2,4-DTBP) with cinnamyl alcohol (Cin-OH) over mesoporous Zn-Al-MCM-41 catalysts synthesized under direct basic hydrothermal method. The main alkylated product, 6,8-DTBF is importantly used as an intermediate in the manufacture of biosynthetic organic compounds. The recyclable mesoporous Zn-Al-MCM-41 catalysts have also been reused in this reaction to study their catalytic activities. The influences of various reaction parameters such as temperature, time, ratios of reactant (2,4-DTBP-to-Cin-OH) have been extensively investigated for the synthesis of 6,8-DTBF. In addition, dimethyl sulfoxide (DMSO) has also been used as a solvent in this catalytic reaction. The mesoporous Zn-Al-MCM-41(75) gives excellent catalytic activity with 6,8-DTBF selectivity (86.0%) and 2,4-DTBP conversion (63.1%), and these catalytic results have also compared with that obtained using other mesoporous and microporous catalysts. On the basis of catalytic activity obtained by using the all catalysts, the Zn-Al-MCM-41(75) catalyst is found to be a highly active, recyclable and eco-friendly heterogeneous catalyst in the liquid-phase alkylation of 2,4-DTBP. The Royal Society of Chemistry 2012.

Mesoporous Aluminosilicate MCM-41 as a Convenient Acid Catalyst for Friedel-Crafts Alkylation of a Bulky Aromatic Compound with Cinnamyl Alcohol

Owing to its large molecular size, alkylation of 2,4-di-tert-butylphenol with cinnamyl alcohol does not take place using HY zeolite (pore opening 7.4 Angstroem) as catalyst even after controlled steaming treatment to increase its mesoporosity; by contrast, novel mesoporous aluminosilicate MCM-41 catalyses this reaction giving rise to 6,8-di-tert-butyl-2-phenyl-2,3-dihydrobenzopyran (arising from intramolecular cyclization of the primary cinnamylphenol) together with 4-tert-butylphenol and small amounts of 6-tert-butyl-2-phenyl-2,3-dihydrobenzopyran.