76345-48-7Relevant academic research and scientific papers
MINERALOCORTICOID RECEPTOR ANTAGONISTS
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, (2013/04/25)
The present invention is directed to compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof, that are aldosterone receptor antagonists which might be useful for treating aldosterone-mediated diseases. The invention furthermore r
Mapping the high-affinity binding domain of 5-substituted benzimidazoles to the proximal N-terminus of the GluN2B subunit of the NMDA receptor
Wee,Ng,Leung,Cheong,Kong,Ng,Soh,Lam,Low, Chian-Ming
scheme or table, p. 449 - 461 (2010/12/25)
Background and purpose: N-methyl-D-aspartate (NMDA) receptors represent an attractive drug target for the treatment of neurological and neurodegenerative disorders associated with glutamate-induced excitotoxicity. The aim of this study was to map the bind
URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C
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Page/Page column 190, (2009/04/25)
Present application relates to the compounds of formula I useful to treat hepatitis C (HCV) infections. In the structure of the disclosed compounds is the uracil or thymine derivative linked via a phenylene into either fused 2-ring cyclic system (R6) or alternatively via additional two-atom linker (L) to a 5-6 membered monocycle (R6). Application further discloses polymorphs and pseudopolymorphs of two specific compounds: N-(6(3-t-butyl-5-(2>4-dioxo-3,4-dihydropyrimidin-1 (2H)- y!)2-methoxy-phenyl)naphthalen-2-yl)methanesulfonamide and (E)-N-(4(3-t- butyl-5-(2,4-dioxo-3)4-dihydropyrimidin-1 (2H)-yl)2-methoxy-styryl- phenyl)methanesulfonamide.
ANTI-INFECTIVE PYRIMIDINES AND USES THEREOF
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Page/Page column 119, (2009/04/25)
This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
Selective Functionalization in 2-Nitro-p-phenylenediamine : Part I - Synthesis of Derivatives of 5-Aminobenzimidazole
Rajappa, S.,Sreenivasan, R.
, p. 533 - 535 (2007/10/02)
2-Nitro-p-phenylenediamine (3) reacts with several electrophilic reagents selectively on the amine meta to the nitro group.The products (4) can be reduced catalytically to the diamines (5) and then cyclized by means of N-carbalkoxy-S-methylpseudothiourea
