76345-45-4

Upstream product

• 5307-14-2 2-nitro-1,4-phenylenediamine 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 117131-14-3 N-cyanomethyl-4-methanesulphonamido-2-nitroaniline 
• 76345-48-7 N-(3,4-diaminophenyl)methanesulfonamide 
• 1430200-22-8 C₂₅H₂₉FN₄O₅S 
• 1430200-31-9 (R)-ethyl 3-(4-fluorophenyl)-2-hydroxy-2-(5-(methylsulfonamido)-1H-benzo[d]imidazol-2-yl)propanoate 
• 1430200-29-5 (R)-ethyl 3-(2-amino-4-(methylsulfonamido)phenylamino)-2-(4-fluorobenzyl)-2-hydroxy-3-oxopropanoate 

Relevant academic research and scientific papers

o-NITROANILINE DERIVATIVES. PART 10. 5- AND 6-AMINO-1H-BENZIMIDAZOLE 3-OXIDES

Cyclisation of N-(4- or 5-acylamino-2-nitrophenyl)glycine esters in basic media gives alkyl 5- or 6-acylaminobenzimidazole-2-carboxylate N-oxides, e.g. (11a) or (11b).Acid hydrolysis of the latter, followed by the reaction of ammonia, gives the title compounds (1b) and (1c), in acceptable yield.The corresponding reaction sequence with 4-acylamino-N-cyanomethyl-o-nitroanilines also gives (1b); where the acyl group is methylsulphonyl, however, the final product is 5-methanesulphonamidobenzimidazole N-oxide (9).Compound (1b) is also obtainable from ethyl 5-nitrobenzimidazole-2-carboxylate N-oxide by reduction followed by hydrolysis.Attempts to cyclise N-(o-nitrophenyl)glycine derivatives containing a free amino group at the 5-position are unsuccessful.This failure is attributed to mesomeric deactivation of the nitro group by the amino lone pair.

MINERALOCORTICOID RECEPTOR ANTAGONISTS

The present invention is directed to compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof, that are aldosterone receptor antagonists which might be useful for treating aldosterone-mediated diseases. The invention furthermore r

Mapping the high-affinity binding domain of 5-substituted benzimidazoles to the proximal N-terminus of the GluN2B subunit of the NMDA receptor

Background and purpose: N-methyl-D-aspartate (NMDA) receptors represent an attractive drug target for the treatment of neurological and neurodegenerative disorders associated with glutamate-induced excitotoxicity. The aim of this study was to map the bind

Selective Functionalization in 2-Nitro-p-phenylenediamine : Part I - Synthesis of Derivatives of 5-Aminobenzimidazole

2-Nitro-p-phenylenediamine (3) reacts with several electrophilic reagents selectively on the amine meta to the nitro group.The products (4) can be reduced catalytically to the diamines (5) and then cyclized by means of N-carbalkoxy-S-methylpseudothiourea