76360-82-2

Basic information

• Product Name: ETHYL 4-(METHYLAMINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE
• Synonyms: ETHYL 4-(METHYLAMINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE;4-(Methylamino)-2-(methylthio)pyrimidine-5-carboxylic Acid Ethyl Ester;4-MethylaMino-2-Methylsulfanyl-pyriMidine-5-carboxylic acid ethyl ester;ethyl 4-(MethylaMino)-2-(Methylsulfanyl)pyriMidine-5-carboxylate;Ethyl 4-(MethylaMino)-2-(Methylthio)pyriMidine-5-carboxylate;NSC 165300;2-(Methylthio)-4-(MethylaMino)-pyriMidine-5-carboxylic acid e;ethyl 2-(Methylthio)-4-(MethylaMino)-pyriMidine-5-carboxylate
• CAS NO: 76360-82-2
• Molecular Formula: C₉H₁₃N₃O₂S
• Molecular Weight: 227.28
• EINECS: 1533716-785-6
• Product Categories: Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 76360-82-2.mol
• Article Data: 43

Chemical Properties

• Melting Point: 91-93 °C
• Boiling Point: 368.9 °C at 760 mmHg
• Flash Point: 176.9 °C
• Appearance: /
• Density: 1.24 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Chloroform, Dichloromethane, DMSO, Ethyl Acetate, Methanol
• PKA: 3.11±0.10(Predicted)
• CAS DataBase Reference: ETHYL 4-(METHYLAMINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-(METHYLAMINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE(76360-82-2)
• EPA Substance Registry System: ETHYL 4-(METHYLAMINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE(76360-82-2)

Safety Data

• Hazardous Substances Data: 76360-82-2(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

An intermediate in the preparation of antitumor agents, antiinflammatory agents and tyrosine kinase inhibitors

InChI:InChI=1S/C9H13N3O2S/c1-4-14-8(13)6-5-11-9(15-3)12-7(6)10-2/h5H,4H2,1-3H3,(H,10,11,12)

Upstream product

• 2223-96-3 4-chloro-2-ethylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester 
• 74-89-5 methylamine 
• 5909-24-0 4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester 
• 593-51-1 methylamine hydrochloride 

Downstream Products

• 1312558-06-7 8-methyl-2-(methylsulfanyl)-6-(phenylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one 
• 1312565-29-9 8-methyl-2-(methylsulfinyl)-6-(phenylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one 

Relevant articles and documents

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FGFR4 kinase inhibitor, preparation method and uses thereof

The present invention relates to a compound represented by a formula (I), or a pharmaceutically acceptable salt, a solvate, a polymorph or an isomer thereof, and uses in preparation of drugs for treatment of FGFR4 mediated diseases.