76362-50-0Relevant academic research and scientific papers
Dehydrooligopeptides. VII. Convenient Synthesis of Various Dehydrodi- and tripeptide Esters by Using N-Carboxy α-Dehydroamino Acid Anhydride
Shin, Chuung-gi,Yonezawa, Yasuchika,Ikeda, Masahiro
, p. 3573 - 3579 (2007/10/02)
The one-pot syntheses of N-protected Δ1- and Δ2-dehydrodipeptide esters by the coupling of N-carboxy α-dehydroamino acid anhydride (ΔNCA) with several kinds of C- or N-protected L-α-amino acids are described.In addition, it was found that a similar coupling of ΔNCA with both C- and N-protected α-amino acids also took place to give Δ2-dehydrotripeptide derivatives, involving eight kinds of important C-terminal segments of antrimycins and cirratiomycins.The configurational confirmation of the α-dehydroisoleucine residue of the antibiotics is also discussed.
FACILE AND USEFUL ONE-POT SYNTHESIS OF DEHYDROOLIGOPEPTIDES USING ΔNCA
Shin, Chung-gi,Yamada, Toyofumi,Yonezawa, Yasuchika
, p. 2175 - 2176 (2007/10/02)
One-pot coupling of ΔNCA with N- and C-terminus α-amino acid, peptide, or dehydropeptide was achieved to give various types of dehydrooligopeptides.
