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Usage

Uses

Used in Pharmaceutical Development:
3-methyl[1,2,4]triazolo[3,4-a]isoquinoline is used as a key intermediate in the synthesis of various pharmaceuticals for its potential to contribute to the biological activity of the resulting compounds. Its unique structure allows for the exploration of its properties in drug discovery and development processes.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 3-methyl[1,2,4]triazolo[3,4-a]isoquinoline serves as a valuable compound for research into its potential therapeutic applications. 3-methyl[1,2,4]triazolo[3,4-a]isoquinoline's structure may offer insights into the design of new drugs with improved efficacy and selectivity.
Used in Bioactive Compounds Synthesis:
3-methyl[1,2,4]triazolo[3,4-a]isoquinoline is utilized as a building block in the creation of bioactive compounds, which are essential in the development of new treatments for various diseases and conditions. Its incorporation into these compounds can enhance their pharmacological properties.

Upstream product

• 19493-44-8 1-chloroisoquinoline 
• 15793-94-9 1-hydrazino-isoquinoline 
• 127-19-5 N,N-dimethyl acetamide 
• 1456807-59-2 1-hydrazinoisoquinoline hydrobromide hydrate 
• 2208-07-3 ethyl acetimidate hydrochloride 

Relevant academic research and scientific papers

Metal free [4+1] and [5+1] annulation reactions to prepare heterocycles using DMF and its derivatives as one-carbon source

1,2,4-Triazolo[3,4-a]pyridines and related heterocycles and substituted triazines were commonly discovered scaffolds in a variety of pharmaceutical and agrochemical agents. Herein, we report a highly efficient and practical method using DMF and its derivative for the [4+1] and [5+1] annulation reactions to prepare these heterocycles. This metal free reaction takes advantages of shelf stable DMF as solvent and carbon donor, imidazole chloride as a catalyst, the mild reaction condition tolerates a broad substrate range and substitutes. The prepared 3-unsubstituted 1,2,4-triazolo[3,4-a]pyridine and derivatives allow further introduction of a variety of functional group1 at 3-position.

A mild synthesis of [1,2,4]triazolo[4,3-a]pyridines

The reaction between 2-hydrazinopyridines and ethyl imidates was examined as a one-pot method for rapidly preparing [1,2,4]triazolo[4,3-a]pyridines. A diverse set of 2-hydrazinopyridines were cyclized with a variety of alkyl- and aryl-substituted ethyl imidates in good yields. The reaction proceeds optimally under mild conditions (50-70 C) using 1.5 equiv of acetic acid. The electronic and steric properties of the hydrazine and imidate strongly impact the rate of the reaction. When highly electron deficient 2-hydrazinopyridines were used, the products rearranged to [1,2,4]triazolo[1,5-a]pyridines.