7639-71-6Relevant articles and documents
Long-Lasting and Fast-Acting in Vivo Efficacious Antiplasmodial Azepanylcarbazole Amino Alcohol
Abla, Nada,Bashyam, Sridevi,Charman, Susan A.,Greco, Béatrice,Hewitt, Philip,Jiménez-Díaz, Maria Belén,Katneni, Kasiram,Kubas, Holger,Picard, Didier,Sambandan, Yuvaraj,Sanz, Laura,Smith, Dennis,Wang, Tai,Willis, Paul,Wittlin, Sergio,Spangenberg, Thomas
, p. 1304 - 1308 (2017)
With ～429,000 deaths in 2016, malaria remains a major infectious disease where the need to treat the fever symptoms, but also to provide relevant post-treatment prophylaxis, is of major importance. An azepanylcarbazole amino alcohol is disclosed with a long- and fast-acting in vivo antiplasmodial efficacy and meets numerous attributes of a desired post-treatment chemoprophylactic antimalarial agent. The synthesis, the parasitological characterization, and the animal pharmacokinetics and pharmacodynamics of this compound are presented along with a proposed target.
A terphenyl phosphine as a highly efficient ligand for palladium-catalysed amination of aryl halides with 1° anilines
Shi, Ji-cheng,Zhang, Lixue,Zhou, Fabin
, p. 238 - 243 (2021/09/07)
A terphenyl phosphine ligand (2,6-bis(2,4,6-triisopropylphenyl)phenyl-dicyclohexylphosphine, TXPhos) and its supported palladium complex [(TXPhos)(allyl)PdCl] have been developed and the catalyst system is highly efficient in amination of aryl halides with 1° anilines, especially effective for densely functionalized substrates including both partners possessing ortho-ester, acetyl, nitrile and nitro groups. With the TXPhos-supported catalyst system, many partner combinations have been unprecedentedly realized and the base scope has been even extended to KOAc, which is even the best choice in the amination of 2-nitrochlorobenzene.
ORGANIC COMPOUNDS, LIGHT EMITTING DIODE AND LIGHT EMITTING DEVICE HAVING THE COMPOUNDS
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Paragraph 0227-0231, (2020/08/07)
The present invention relates to an organic compound having a condensed aromatic core with a fluorene moiety and substituted with one or more functional groups having excellent hole transport properties, and a light emitting diode and a light emitting device using the same. According to the present invention, the organic compound can be introduced into a light emitting diode by using a solution process, and has a very deep HOMO energy level. When the organic compound of the present invention is applied to a hole transport layer, a band gap of the HOMO energy level between the hole transport layer and a light emitting material layer can be reduced, and thus holes and electrons can be injected into the light emitting material layer in a balanced manner. Accordingly, the light emitting diode and the light emitting device capable of low-voltage driving with higher light emitting efficiency can be implemented.COPYRIGHT KIPO 2020
A Unified and Practical Method for Carbon–Heteroatom Cross-Coupling using Nickel/Photo Dual Catalysis
Escobar, Randolph A.,Johannes, Jeffrey W.
supporting information, (2020/04/17)
While carbon–heteroatom cross-coupling reactions have been extensively studied, many methods are specific and limited to a particular set of substrates or functional groups. Reported here is a general method that allows for C?O, C?N and C?S cross-coupling reactions under one general set of conditions. We propose that an energy transfer pathway, in which an iridium photosensitizer produces an excited nickel(II) complex, is responsible for the key reductive elimination step that couples aryl bromides, iodides, and chlorides to 1° and 2° alcohols, amines, thiols, carbamates, and sulfonamides, and is amenable to scale up via a flow apparatus.
Amination of Aryl Boronic Acids with Alkylnitrites: A Convenient Complement to Cu-Promoted Reductive Amination
Levitskiy, Oleg A.,Magdesieva, Tatiana V.
, p. 10028 - 10032 (2019/12/24)
Copper-catalyzed amination of aryl boronic acids with alkylnitrites leading to symmetrical diarylamines with a practical 50-80% yield was elaborated. Two C(sp2)-N bonds are formed in the one-pot process under mild conditions. This new approach to diarylamines is a complement to the Cu-assisted reductive amination of aryl boronic acids avoiding preliminary synthesis of nitrosoarenes. The possible reaction scheme based on quantum chemical calculations was suggested, clarifying key intermediates.
AZEPANYL-DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME WITH ANTIPARASITIC ACTIVITY
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Page/Page column 77; 78, (2016/01/25)
The present invention provides compounds of Formula (i). Furthermore, pharmaceutical compositions are provided comprising at least one compound of Formula (i), for the treatment of parasitic diseases including malaria, as well as neurodegenerative diseases.
PIPERIDINYLCARBAZOLE AS ANTIMALARIAL
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Page/Page column 85, (2014/07/23)
The present invention provides compounds of Formula (I) for the treatment of parasitic diseases including malaria, as well as neurodegenerative diseases. Formula (I) wherein R3, R4, X and Y have the meaning given in claim 1.
Selective one-pot synthesis of symmetrical and unsymmetrical di- and triarylamines with a ligandless copper catalytic system
Tlili, Anis,Monnier, Florian,Taillefer, Marc
supporting information; experimental part, p. 6408 - 6410 (2012/07/27)
The one-pot synthesis of symmetrical or unsymmetrical di- or triarylamines using aryl iodides or bromides and LiNH2 as ammonia source is reported. This highly selective method is based, for the first time, on a copper-catalyzed system, which does not require the presence of any additional ligand.
Substituted Triarylamine Cation-Radical Redox Systems - Synthesis, Electrochemical and Spectroscopic Properties, Hammet Behavior, and Suitability as Redox Catalysts
Dapperheld, Steffen,Steckhan, Eberhard,Grosse Brinkhaus, Karl-Heinz,Esch, Thomas
, p. 2557 - 2568 (2007/10/02)
21 triarylamines (1n - 1z, 1za, 1zb) and triarylamine analogs (2a, 2b, 3a, 3b, 4a, 4b) with substituents in at least all three p positions and some of their cation-radical hexachloroantimonates have been synthesized.The electrochemical behavior has been studied by cyclic voltammetry.Most of the compounds show chemically and electrochemically reversible first oxidation waves in the formation of the cation radicals.With the exception of 4a and 4b, the second wave for the formation of the dication is chemically irreversible.The UV spectra of the triarylamine cation radicals have been obtained in the presence of a slight excess of SbCl5.A good Hammett correlation between the first anodic potential of only p-substituted triarylamines and the ?/?+ values has been established.Some redox-catalytic properties of triarylamine cation radicals are described. Key Words: Triarylamines / Cation radicals / Electrochemistry / Redox catalysts / Voltammetry, cyclic
