76395-72-7

Basic information

• Product Name: Piperidine, 1-(chloroacetyl)-2-ethyl- (9CI)
• Synonyms: Piperidine, 1-(chloroacetyl)-2-ethyl- (9CI);1-(Chloroacetyl)-2-ethylpiperidine;2-chloro-1-(2-ethyl-1-piperidinyl)ethanone;2-chloro-1-(2-ethyl-1-piperidyl)ethanone;2-chloro-1-(2-ethylpiperidin-1-yl)ethanone;T0514-5264
• CAS NO: 76395-72-7
• Molecular Formula: C9H16ClNO
• Molecular Weight: 189.68244
• Product Categories: ACETYLHALIDE
• Mol File: 76395-72-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 292.1±23.0 °C(Predicted)
• Appearance: /
• Density: 1.067±0.06 g/cm3(Predicted)
• PKA: -0.89±0.40(Predicted)
• CAS DataBase Reference: Piperidine, 1-(chloroacetyl)-2-ethyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine, 1-(chloroacetyl)-2-ethyl- (9CI)(76395-72-7)
• EPA Substance Registry System: Piperidine, 1-(chloroacetyl)-2-ethyl- (9CI)(76395-72-7)

Safety Data

• Hazardous Substances Data: 76395-72-7(Hazardous Substances Data)

Upstream product

• 79-04-9 chloroacetyl chloride 
• 1484-80-6 2-ethylpiperidine 

Relevant articles and documents

Synthesis, spectral studies and anti-inflammatory activity of glycolamide esters of niflumic acid as potential prodrugs

In order to reduce the gastric irritation caused by direct contract mechanism of the carboxylic acid group, a series of glycolamide esters of niflumic (CAS 4394-00-7) (1) have been prepared as biolabile prodrugs by reacting appropriate 2-chloroacetamides with niflumic acid. The required 2-chloroacetamides were obtained by the condensation of chloroacetyl chloride and corresponding amine. Their structures were confirmed by UV, IR and 1H NMR spectra. Selected compounds were evaluated for anti-inflammatory activity in carrageenan induced paw oedema in rats at the doses of 45, 90 and 150 mg/kg b.w. Prodrugs showed comparable anti-inflammatory activity (67.1-79.4%) at 150 mg/kg b.w. with respect to niflumic acid (70.3%) at 45 mg/kg b.w., indicating moderate release of niflumic acid in vivo. The highest activity was observed with diethylamine (4) and pyrrolidine (9) derivatives.