76407-01-7Relevant academic research and scientific papers
2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists
Scheiff, Anja B.,Yerande, Swapnil G.,El-Tayeb, Ali,Li, Wenjin,Inamdar, Gajanan S.,Vasu, Kamala K.,Sudarsanam, Vasudevan,Müller, Christa E.
, p. 2195 - 2203 (2010)
A series of 2-amino-5-benzoyl-4-phenylthiazole derivatives was investigated in radioligand binding studies at adenosine receptor (AdoR) subtypes with the goal to obtain potent and A1-selective antagonists. Acylation of the 2-amino group was fou
Design, synthesis and characterization of novel 2-(2,4-disubstituted-thiazole-5-yl)-3-aryl-3H-quinazoline-4-one derivatives as inhibitors of NF-κB and AP-1 mediated transcription activation and as potential anti-inflammatory agents
Giri, Rajan S.,Thaker, Hardik M.,Giordano, Tony,Williams, Jill,Rogers, Donna,Sudersanam, Vasudevan,Vasu, Kamala K.
body text, p. 2184 - 2189 (2009/09/30)
A series of 2-(2,4-disubstituted-thiazole-5-yl)-3-aryl-3H-quinazoline-4-one derivatives were designed and synthesized. Synthesized molecules were further evaluated for their inhibitory activity towards transcription factors NF-κB and AP-1 mediated transcr
