76409-79-5Relevant academic research and scientific papers
Synthesis and Biological Activity of Analogues of β-Chlornaltrexamine and β-Funaltrexamine at Opioid Receptors
Portoghese, P. S.,Rein, Michael D.,Takemori, A. E.
, p. 1861 - 1864 (1986)
β-Chlornaltrexamine and β-funaltrexamine analogues 4-7 with different length "arms" to which an electrophilic moiety is attached were synthesized in an effort to obtain affinity labels that would selectively and irreversibly block specific opioid receptor types and subtypes.One of the compounds, 4, was a potent, irreversible blocker of opioid receptors in the guinea pig ileum and mouse vas deferens preparations.The results of this study suggest that nucleophiles that are remote from the recognition locus are capable of alkylation by reactive electrophiles.
Synthesis of model compounds for potential contrast agents containing phosphonate and peptide moieties
Shalem, Hutti,Shatzmiller, Shimon,Feit, Ben-Ami
, p. 2831 - 2837 (2007/10/03)
The synthesis of dimethyl 2-acetoxy-2-(2,4-diiodo-5-aminophenyl)ethylphosphonate and dimethyl 2-acetoxy-2-(2,4,6-triiodo-3,5-diaminophenyl)ethylphosphonate is described. Several amido and peptidic derivatives of these two compounds were prepared. These products are composed of a combination of structural/functional moieties which pave the way for their potential application as non-ionic selective X-ray contrast agents. The Royal Society of Chemistry 2000.
Synthesis and radiation-protective properties of dipeptide derivatives of S-(2-aminoethyl) phosphothioates and S-butyryl-2-aminoethanethiol
Malov,Semenova,Krasil'nikov,Arapov
, p. 1280 - 1284 (2007/10/03)
Possibility of preparing dipeptide (with various N-protective groups and amino acid residues) derivatives of S-(2-aminoethyl) phosphothioates, S-butyryl-2-aminoethylethanethiol, and also S-(2-aminoethyl)isothiuronium is examined. The radiation-protective properties of these compounds are studied.
