Journal of Medicinal Chemistry p. 1861 - 1864 (1986)
Update date:2022-08-03
Topics:
Portoghese, P. S.
Rein, Michael D.
Takemori, A. E.
β-Chlornaltrexamine and β-funaltrexamine analogues 4-7 with different length "arms" to which an electrophilic moiety is attached were synthesized in an effort to obtain affinity labels that would selectively and irreversibly block specific opioid receptor types and subtypes.One of the compounds, 4, was a potent, irreversible blocker of opioid receptors in the guinea pig ileum and mouse vas deferens preparations.The results of this study suggest that nucleophiles that are remote from the recognition locus are capable of alkylation by reactive electrophiles.
View MorePengchen New Material Technology Co., Ltd.
Contact:+86-512-63680537
Address:99.6 km of national road 318, Meiyan Community,Pingwang Town, Wujiang District, Suzhou 215225
Contact:+86-25-83719363
Address:106-7 Chunnan Rd, Chunxi Town, Gaochun, Nanjing, China
Contact:
Address:ROOM 1715, No#345 Jin Xiang Road, Pudong District
Suzhou Sinosun Imp.&Exp. Corporation
website:http://www.szsinosun.com
Contact:+86-512-63488895,63488616
Address:No.758 East Jiangling Road Wujiang Economic & Technological Developmenty Zone Jiangsu China
Suzhou Chiral Pharmaceuticals Co., Ltd.
Contact:86-0512-63197058
Address:Building A, No. 2358, Chang'an Road, Wujiang Science Park
Doi:10.1021/jo00063a024
(1993)Doi:10.1002/jps.2600810910
(1992)Doi:10.1246/cl.1980.1315
(1980)Doi:10.1021/jo049477+
(2004)Doi:10.1021/ja00545a060
(1980)Doi:10.1016/0039-128X(80)90030-6
(1980)
