7641-27-2

Basic information

• Product Name: 2-phenyl-4-(trifluoromethyl)-1H-benzo[d]imidazole
• Synonyms: 2-phenyl-4-(trifluoromethyl)-1H-benzo[d]imidazole
• CAS NO: 7641-27-2
• Molecular Weight: 262.234
• Mol File: 7641-27-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-phenyl-4-(trifluoromethyl)-1H-benzo[d]imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-4-(trifluoromethyl)-1H-benzo[d]imidazole(7641-27-2)
• EPA Substance Registry System: 2-phenyl-4-(trifluoromethyl)-1H-benzo[d]imidazole(7641-27-2)

Safety Data

• Hazardous Substances Data: 7641-27-2(Hazardous Substances Data)

Upstream product

• 24821-17-8 2-Nitro-6-(trifluoromethyl)aniline 
• 707-07-3 orthobenzoic acid trimethyl ester 
• 887144-97-0 Togni's reagent 
• 716-79-0 2-phenyl-1H-benzoimidazole 

Relevant articles and documents

Indium-mediated one-pot benzimidazole synthesis from 2-nitroanilines or 1,2-dinitroarenes with orthoesters

One-pot reduction-triggered heterocyclizations from 2-nitroanilines or 1,2-dinitroarenes to benzimidazoles were investigated in this study. In the presence of indium/AcOH in ethyl acetate at reflux, reaction of 2-nitroanilines or 1,2-dinitroarenes with R-C(OMe)3 (R=Me, Ph) produced excellent yields of the corresponding benzimidazoles within 30 min to 6 h depending on the substituents of the starting materials. Indium-mediated heterocyclization of 2-nitroanilines to benzimidazole was faster and had better yields than 1,2-dinitroarenes to benzimidazole under similar reaction conditions.