76429-85-1

Basic information

• Product Name: DEACETYLTAXOL B, 10-(RG)
• Synonyms: DEACETYLTAXOL B, 10-(RG);(αR,βS)-α-Hydroxy-β-[[(2E)-2-Methyl-1-oxo-2-buten-1-yl]aMino]benzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)- 2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetraMethyl-5-oxo-7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester;10β-DeacetylcephaloManine
• CAS NO: 76429-85-1
• Molecular Formula: C₄₃H₅₁NO₁₃
• Molecular Weight: 789.86394
• Product Categories: Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 76429-85-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 930.8°Cat760mmHg
• Flash Point: 516.7°C
• Appearance: /
• Density: 1.37g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.627
• CAS DataBase Reference: DEACETYLTAXOL B, 10-(RG)(CAS DataBase Reference)
• NIST Chemistry Reference: DEACETYLTAXOL B, 10-(RG)(76429-85-1)
• EPA Substance Registry System: DEACETYLTAXOL B, 10-(RG)(76429-85-1)

Safety Data

• Hazardous Substances Data: 76429-85-1(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

10-Deacetyl Cephalomannine is a derivative of Cephalomannine (C258500).

InChI:InChI=1/C43H51NO13/c1-8-22(2)37(50)44-31(25-15-11-9-12-16-25)33(48)39(52)55-27-20-43(53)36(56-38(51)26-17-13-10-14-18-26)34-41(7,35(49)32(47)30(23(27)3)40(43,5)6)28(46)19-29-42(34,21-54-29)57-24(4)45/h8-18,27-29,31-34,36,46-48,53H,19-21H2,1-7H3,(H,44,50)/b22-8+/t27-,28-,29+,31-,32+,33+,34-,36-,41+,42-,43+/m0/s1

Upstream product

• 71610-00-9 cephalomannine 
• 71610-00-9 Cephalomannine 

Downstream Products

• 861856-91-9 2'-acetylcephalomannine 
• 651293-91-3 C₄₉H₆₅NO₁₃Si 

Relevant articles and documents

The Reductive Fragmentation of 7-Hydroxy-9,10-dioxotaxoids

The retro-aldol reductive fragmentation of different structural types of 7-hydroxy-9,10-dioxotaxoids was investigated, showing that the reaction is typical of taxanes and requires cerium(III) promotion with NaBH4 in protic medium and alkylboron (aluminium) hydrides in aprotic solvents. The resulting 7,8-seco-taxanes are key intermediates for the synthesis of a novel class of anticancer taxanes endowed with a unique pattern of in vivo biological activity. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

Anitleukemic Alkaloids from Taxus wallichiana Zucc.

A new antileukemic taxane alkaloid, cephalomannine (1a), has been isolated from leaves, stems, and roots of Taxus wallichiana Zucc.Cephalomannine is closely related to taxol (1b), a previously characterized antileukemic alkaloid, which also occurs in T. wallichiana but in lesser amounts than cephalomannine.The new alkaloid and its hydrolysis products were characterized by nuclear magnetic resonance, mass spetroscopy, and X-ray crystallography; taxol and two cytotoxic taxane congeners were also identified.