76440-44-3Relevant articles and documents
Asymmetric Michael addition of arylthiols to α,β-unsaturated carbonyl compounds catalyzed by bifunctional organocatalysts
Li, Bang-Jing,Jiang, Lin,Liu, Min,Chen, Ying-Chun,Ding, Li-Sheng,Wu, Yong
, p. 603 - 606 (2005)
Bifunctional chiral organocatalysts comprising thiourea and tertiary amine groups were synthesized. They act as efficient catalysts for asymmetric Michael addition of arylthiols to α,β-unsaturated carbonyl compounds. Enantioselectivity up to 85% has been achieved. Asymmetric α-protonation reaction (up to 60% ee) can be obtained in the presence of the bifunctional catalyst.
Combined bead polymerization and Cinchona organocatalyst immobilization by thiol-ene addition
Fredriksen, Kim A.,Kristensen, Tor E.,Hansen, Tore
experimental part, p. 1126 - 1133 (2012/09/05)
In this work, we report an unusually concise immobilization of Cinchona organocatalysts using thiol-ene chemistry, in which catalyst immobilization and bead polymerization is combined in a single step. A solution of azo initiator, polyfunctional thiol, polyfunctional alkene and an unmodified Cinchona-derived organocatalyst in a solvent is suspended in water and copolymerized on heating by thiol-ene additions. The resultant spherical and gel-type polymer beads have been evaluated as organocatalysts in catalytic asymmetric transformations.
Addition of Aromatic Thiols to Conjugated Cycloalkenones, Catalyzed by Chiral β-Hydroxy Amines. A Mechanistic Study on Homogeneous Catalytic Asymmetric Synthesis
Hiemstra, Henk,Wynberg, Hans
, p. 417 - 430 (2007/10/02)
Reactions between aromatic thiols and conjugated cycloalkenones afford optically active 3-arylthiocycloalkanones, when chiral bases are used as catalysts.This paper reports a detailed investigation into the mechanism of this catalytic asymmetric synthesis
