76457-90-4Relevant academic research and scientific papers
Synthesis and biological evaluation of novel glycosyl-containing 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives as acetylcholinesterase inhibitors
Liu, Xiu-Jian,Wang, Lei,Yin, Long,Cheng, Feng-Chang,Sun, Hui-Min,Liu, Wei-Wei,Shia, Da-Hua,Caoa, Zhi-Ling
, p. 571 - 575 (2017/11/14)
An efficient protocol for the synthesis of novel glycosyl-containing 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives starting from the commercially available d-glucosamine hydrochloride is described by reaction of glycosyl isothiocyanate with various aminotriazoles in DMF. Glycosyl isothiocyanate is an important intermediate and synthetic methods are discussed. The acetylcholinesterase inhibitory activity of these compounds was tested by Ellman’s method. It was found that most compounds exhibited over 90% inhibition and they were subsequently evaluated for their IC50values.
Synthesis and anti-inflammatory activity of 4-substituted-2,5-disubstituted indolyl azetidine-3-yl/thiazolidin-1-yl-substituted triazoles
Chandra, Trilok,Garg, Neha,Kumar, Ashok
experimental part, p. 243 - 252 (2010/08/07)
A new series of 4-[2′-(substituted phenyl)-5′-methoxy indolyl azetidine-l-yl/thiazolin-1-yl-3-(substituted phenyl)-5-mercapto-l,2,4-triazoles were designed, synthesized and tested for anti-inflammatory and analgesic activities. All compounds were screened in vitro for anti-inflammatory activity against carrageenan induced rat paw oedema and tested for their analgesic activity against phenyl quinone induced pain syndrome in mice at a dose of 50 mg/kg p.o. All the compounds of this series have been analyzed and confirmed by elemental (C, H, N) and spectral methods, i.e. I.R., 1HNMR, 13C NMR and mass spectrometry data.
Studies on synthesis and pharmacological activities of 1,2,4- triazolo[3,4-b]1,3,4-thiadiazoles and their dihydro analogues
Mathew, Vinod,Giles, Devasahayam,Keshavayya, Jathi,Vaidya, Vijaya P.
experimental part, p. 210 - 222 (2009/05/27)
4-Amino-5-substituted aryl-3-mercapto-1,2,4-triazoles are versatile synthons for constructing various biologically active heterocycles. Starting from 4-amino-5-substituted aryl-3-mercapto-1,2,4- triazole 3a-c, a series of new 3,5-disubstituted-1,2,4-triazolo-[3,4-b]1,3,4-thiadiazoles and their 5,6-dihydrotriazolothiadiazoles were prepared. The structures of all the newly synthesized compounds have been confirmed by elemental analysis, IR, 1H-NMR, 13C-NMR, and mass spectra. The antimicrobial effects of the synthesized compounds were investigated using the paper disc method. Anti-inflammatory and analgesic activities of the synthesized compounds were assessed by carrageenan-induced rat paw oedema method and by Eddy's hot plate method, respectively. Some of the compounds exhibited promising antimicrobial activities as well as moderate to good anti-inflammatory activity and analgesic activity.
Heterocyclic system containing bridgehead nitrogen atom: synthesis and pharmacological activities of some substituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles
Mathew,Keshavayya,Vaidya
, p. 1048 - 1058 (2007/10/03)
Several 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadizoles were prepared by the condensation of 4-amino-3-aryl/aralkyl substituted-5-mercapto-1,2,4-triazoles 3(a-c) with various substituted aromatic/hetero aromatic acids through a single step react
