7646-72-2

Usage

Physical state

Colorless to pale yellow liquid

Odor

Sweet, floral

Uses

Production of pharmaceuticals, intermediate in organic synthesis, fragrance ingredient in perfumes and cosmetics

Safety precautions

Flammable, may cause skin and eye irritation, follow proper safety protocols for handling and storage.

Upstream product

• 10342-83-3 4'-Bromopropiophenone 
• 2768-02-7 (vinyl)trimethoxylsilane 

Relevant academic research and scientific papers

Nickel-Catalyzed Ligand-Free Hiyama Coupling of Aryl Bromides and Vinyltrimethoxysilane

We herein disclose the first Ni-catalyzed Hiyama coupling of aryl halides with vinylsilanes. This protocol uses cheap, nontoxic, and stable vinyltrimethoxysilane as the vinyl donor, proceeds under mild and ligand-free conditions, furnishing a diverse variety of styrene derivatives in high yields with excellent functional group compatibility.

Transition-metal-free regioselective synthesis of alkylboronates from arylacetylenes and vinyl arenes

A transition-metal-free synthesis of alkylboronates, utilizing arylacetylenes or vinyl arenes and bis(pinacolato)diboron through tandem borylation and protodeboronation, has been developed. This reaction is efficient, practical and environmentally benign, leading to anti-Markovnikov products with excellent regioselectivity, broad functional group tolerance and excellent yields in both small and gram scales.